INHBB - inhibin subunit beta B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3625

About INHBB

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:120,346,136-120,351,803 (from NCBI)

This gene has 1 transcript (splice variant), 266 orthologues and 31 paralogues. Biased expression in fat (RPKM 16.6), testis (RPKM 13.1) and 13 other tissues.

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

INHBB Products (1)

mRNA Protein Name
NM_002193.4 NP_002184.2 inhibin beta B chain preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2575216 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
2575216 GOA
Biological Process GO Annotation Evidence References Source
involved in activin receptor signaling pathway IDA
IDA: Inferred from direct assay
16650820 GOA
involved in negative regulation of follicle-stimulating hormone secretion IPI
IPI: Inferred from physical interaction
3122219 GOA
involved in negative regulation of hepatocyte growth factor production IDA
IDA: Inferred from direct assay
12419948 GOA
involved in positive regulation of follicle-stimulating hormone secretion IPI
IPI: Inferred from physical interaction
3122219 GOA
involved in response to wounding IEP
IEP: Inferred from expression pattern
10320815 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16650820 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INHBB Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (66 - 278)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (301 - 406)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

inhibin beta B chain

  • Inhibin, beta-2

Recombinant INHBB Proteins

Cat. No. Product Name Accession Purity
HY-P73242 INHBB Protein, Human (HEK293, His) P09529/NP_002184.2 (S29-A407) ≥ 95%, as determined by reducing SDS-PAGE.

INHBB Antibodies

Cat. No. Product Name Application Reactivity
HY-P811098 Inhibin beta B Antibody WB, ICC/IF Human, Mouse, Rat
HY-P81932 Inhibin beta B Antibody (YA1677) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Eclampsia

  • Eclampsia In Puerperium

  • Postpartum Eclampsia

  • Eclampsia, Postpartum

  • Puerperal Eclampsia
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Dyskeratosis Congenita, Autosomal Recessive 2

  • DKCB2

  • Autosomal Recessive Dyskeratosis Congenita 2

  • Dyskeratosis Congenita, Autosomal Recessive, 2

  • Dyskeratosis Congenita, Autosomal Recessive, Type 2
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06814 INHBB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19015 Inhbb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25504 Inhbb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990454 Anti-INHBB/Activin B Antibody 95.09% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus INHBB MGD MGI:96571
Canis familiaris INHBB VGNC VGNC:42022
Bos taurus INHBB VGNC VGNC:30201
Rattus norvegicus INHBB RGD RGD:2913
Felis catus INHBB VGNC VGNC:107566
Macaca mulatta INHBB VGNC VGNC:104539
Others INHBB NCBI