INHBB - inhibin subunit beta B Gene

Homo sapiens

Gene ID: 3625 | Gene type: protein coding

About INHBB

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:120,346,136-120,351,803 (from NCBI)

This gene has 1 transcript (splice variant), 266 orthologues and 31 paralogues. Biased expression in fat (RPKM 16.6), testis (RPKM 13.1) and 13 other tissues.

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

INHBB Products(1)

mRNA	Protein	Name
NM_002193.4	NP_002184.2	inhibin beta B chain preproprotein

INHBB Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

inhibin beta B chain

Inhibin, beta-2

Recombinant INHBB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73242	INHBB Protein, Human (HEK293, His)	P09529/NP_002184.2 (S29-A407)	≥95%
HY-P700013AF	Animal-Free Activin B Protein, Human (His)	P09529 (G293-407A)	≥95%
HY-P700647	Activin B Protein, Human (CHO)	P09529 (G293-A407)	≥95%

Related Diseases

Diseases

Alias

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Dyskeratosis Congenita, Autosomal Recessive 2

DKCB2	Autosomal Recessive Dyskeratosis Congenita 2
Dyskeratosis Congenita, Autosomal Recessive, 2	Dyskeratosis Congenita, Autosomal Recessive, Type 2

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06814	INHBB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	INHBB	MGD	MGI:96571
Canis familiaris	INHBB	VGNC	VGNC:42022
Bos taurus	INHBB	VGNC	VGNC:30201
Rattus norvegicus	INHBB	RGD	RGD:2913
Felis catus	INHBB	VGNC	VGNC:107566
Macaca mulatta	INHBB	VGNC	VGNC:104539
Others	INHBB	NCBI

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