Inhibin beta B Antibody (YA1677)

Cat. No.: HY-P81932: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Inhibin beta B Antibody (YA1677) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Inhibin beta B.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Inhibin beta B Antibody (YA1677) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Inhibin beta B Antibody (YA1677) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Inhibin beta B.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 45 kDa;

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P09529

Gene ID

3625 [NCBI]

Immunogen

A synthesized peptide derived from human Inhibin beta B aa350-407/407.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 50 mM Tris-Glycine(pH 7.4), 0.15 M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing (PubMed:22611157, PubMed:15196700). Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A or BMPR2 (PubMed:35643319). Upon ligand binding, these receptors phosphorylate intracellular signaling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression (PubMed:15196700). Plays a crucial role in the induction of hepcidin by inflammation through activation of ACVR1C and subsequent phosphorylation of SMAD1/5/8 (PubMed:22611157). Regulates adipocyte lipid metabolism by decreasing non-esterified fatty acids and glycerol release and increases intracellular triglyceride content (By similarity). Stimulates wound healing by promoting cell migration and hair follicle regeneration through the JNK and ERK signaling pathways downstream of RHOA (By similarity); Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)

Subcellular Localization：Secreted

Subunit：Dimeric, linked by one or more disulfide bonds. Inhibin B is a dimer of alpha and beta-B. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3. Activin B interacts with BMPR2 (PubMed:35643319)

Database

Entrez Gene: 3625 Human ; 16324 Mouse ; 25196 Rat

SwissProt: P09529 Human ; Q04999 Mouse ; P17491 Rat

OMIM: 147390 Human

Research Field

Signal Transduction

Synonyms

Activin beta B; INHBB

Documentation

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

Inhibin beta B Antibody (YA1677) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inhibin beta B Antibody (YA1677)

Inhibin beta B Antibody (YA1677) Featured Recommendations:

Product Detail

Background

Documentation

Inhibin beta B Antibody (YA1677) Related Classifications

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