2. Gene
  3. ITPKA - inositol-trisphosphate 3-kinase A Gene

ITPKA - inositol-trisphosphate 3-kinase A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as IP3KA; IP3-3KA

Gene ID: 3706 | Gene type: protein coding

About ITPKA

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,493,874-41,503,551 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 6 paralogues. Biased expression in brain (RPKM 9.4), duodenum (RPKM 6.8) and 5 other tissues.

Summary

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/Calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

ITPKA Products(1)

mRNA Protein Name
NM_002220.3 NP_002211.1 inositol-trisphosphate 3-kinase A

ITPKA Protein Structure

IPK

IPK: Inositol polyphosphate kinase (245 - 455)

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  • 461 a.a.
Protein Preferred Names Protein Names

inositol-trisphosphate 3-kinase A

IP3 3-kinase A

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126750 GNF362 Inhibitor 99.63% Unkown
HY-16694 BAMB-4 Inhibitor 99.99% Unkown
HY-RS06988 ITPKA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ITPKA RGD RGD:619950
Bos taurus ITPKA VGNC VGNC:30344
Canis familiaris ITPKA VGNC VGNC:42154
Macaca mulatta ITPKA VGNC VGNC:73803
Mus musculus ITPKA MGD MGI:1333822
Felis catus ITPKA VGNC VGNC:67867