ITPKA - inositol-trisphosphate 3-kinase A Gene

Also Known as IP3KA; IP3-3KA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3706

About ITPKA

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,493,874-41,503,551 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 6 paralogues. Biased expression in brain (RPKM 9.4), duodenum (RPKM 6.8) and 5 other tissues.

Summary

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/Calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

ITPKA Products (1)

mRNA Protein Name
NM_002220.3 NP_002211.1 inositol-trisphosphate 3-kinase A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
IDA: Inferred from direct assay
1847047 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
12747803 GOA
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
1847047 GOA
involved in response to calcium ion IDA
IDA: Inferred from direct assay
1847047 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoskeleton IDA
IDA: Inferred from direct assay
1847047 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITPKA Protein Structure

IPK

IPK: Inositol polyphosphate kinase (245 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

inositol-trisphosphate 3-kinase A

  • IP3 3-kinase A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126750 GNF362 Inhibitor 99.86% Unkown
HY-16694 BAMB-4 Inhibitor 99.99% Unkown
HY-RS06988 ITPKA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19209 Itpka Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25698 Itpka Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ITPKA RGD RGD:619950
Bos taurus ITPKA VGNC VGNC:30344
Canis familiaris ITPKA VGNC VGNC:42154
Macaca mulatta ITPKA VGNC VGNC:73803
Mus musculus ITPKA MGD MGI:1333822
Felis catus ITPKA VGNC VGNC:67867
Others ITPKA NCBI