2. Gene
  3. Mreg - melanoregulin Gene

Mreg - melanoregulin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as dsu; Wdt2; Gm974

Gene ID: 381269 | Gene type: protein coding

About Mreg

Summary

Enables phosphatidylinositol binding activity. Involved in melanosome localization; minus-end-directed organelle transport along microtubule; and phagosome maturation. Acts upstream of or within melanocyte differentiation and melanosome transport. Located in late endosome membrane and melanosome membrane. Is intrinsic component of organelle membrane. Part of protein-containing complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; liver; and lung. Orthologous to human MREG (melanoregulin). [provided by Alliance of Genome Resources, Apr 2022]

Mreg Products(2)

mRNA Protein Name
NM_001005423.3 NP_001005423.1 melanoregulin isoform 1
NM_001357488.2 NP_001344417.1 melanoregulin isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
19240024 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23523350 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within anagen IMP
IMP: Inferred from mutant phenotype
15550542 MGI
acts upstream of or within developmental pigmentation IMP
IMP: Inferred from mutant phenotype
15550542 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
involved in melanosome localization IMP
IMP: Inferred from mutant phenotype
22940130 MGI
acts upstream of or within melanosome transport IDA
IDA: Inferred from direct assay
22275436 MGI
involved in minus-end-directed organelle transport along microtubule IMP
IMP: Inferred from mutant phenotype
30174147 MGI
involved in phagosome maturation IMP
IMP: Inferred from mutant phenotype
19240024 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
2379821 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
19240024 MGI
located in late endosome membrane IDA
IDA: Inferred from direct assay
30174147 MGI
located in melanosome IDA
IDA: Inferred from direct assay
22275436 MGI
located in melanosome membrane IDA
IDA: Inferred from direct assay
22940130 MGI
located in organelle membrane IDA
IDA: Inferred from direct assay
22940130 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
22275436 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melanoregulin

dilute suppressor protein

whn-dependent transcript 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08644 MREG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mreg NCBI NCBI:55686