MREG - melanoregulin Gene

Homo sapiens

Also known as DSU; WDT2

Gene ID: 55686 | Gene type: protein coding

About MREG

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:215,939,308-216,034,096 (from NCBI)

This gene has 5 transcripts (splice variants) and 118 orthologues. Broad expression in esophagus (RPKM 7.4), skin (RPKM 5.3) and 22 other tissues.

Summary

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in melanocyte differentiation; melanosome transport; and phagosome maturation. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be intrinsic component of organelle membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. [provided by Alliance of Genome Resources, Apr 2022]

MREG Products(4)

mRNA	Protein	Name
NM_001372188.1	NP_001359117.1	melanoregulin isoform 1
NM_001372189.1	NP_001359118.1	melanoregulin isoform 3
NM_001372190.1	NP_001359119.1	melanoregulin isoform 3
NM_018000.3	NP_060470.2	melanoregulin isoform 2

Protein Preferred Names

Protein Names

melanoregulin

dilute suppressor protein homolog

Related Diseases

Diseases

Alias

Neuroaspergillosis

Brugada Syndrome 2

BRGDA2

Brugada Syndrome, Type 2

Jaw Cancer

Jaw Neoplasms	Jaw Neoplasm
Neoplasm Of Jaw	Cancer Of Jaw

Reflex Epilepsy

Epilepsy, Reflex	Epilepsy, Sensory-Induced
Epilepsy Reflex

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08644	MREG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MREG	VGNC	VGNC:43362
Rattus norvegicus	MREG	RGD	RGD:1562333
Macaca mulatta	MREG	VGNC	VGNC:74826
Bos taurus	MREG	VGNC	VGNC:31601
Felis catus	MREG	VGNC	VGNC:107583
Mus musculus	MREG	MGD	MGI:2151839