MREG - melanoregulin Gene

Also Known as DSU; WDT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55686

About MREG

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:215,939,308-216,034,096 (from NCBI)

This gene has 5 transcripts (splice variants) and 118 orthologues. Broad expression in esophagus (RPKM 7.4), skin (RPKM 5.3) and 22 other tissues.

Summary

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in melanocyte differentiation; melanosome transport; and phagosome maturation. Predicted to act upstream of or within developmental pigmentation. Predicted to be located in late endosome membrane and melanosome membrane. Predicted to be intrinsic component of organelle membrane. Predicted to be part of protein-containing complex. Predicted to be active in melanosome. [provided by Alliance of Genome Resources, Apr 2022]

MREG Products (4)

mRNA Protein Name
NM_001372188.1 NP_001359117.1 melanoregulin isoform 1
NM_001372189.1 NP_001359118.1 melanoregulin isoform 3
NM_001372190.1 NP_001359119.1 melanoregulin isoform 3
NM_018000.3 NP_060470.2 melanoregulin isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melanoregulin

  • dilute suppressor protein homolog

MREG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MREG Q8N565 EIF1AD Homo sapiens Q8N9N8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuroaspergillosis
Brugada Syndrome 2

  • BRGDA2

  • Brugada Syndrome, Type 2
Jaw Cancer

  • Jaw Neoplasms

  • Jaw Neoplasm

  • Neoplasm Of Jaw

  • Cancer Of Jaw
Reflex Epilepsy

  • Epilepsy, Reflex

  • Epilepsy, Sensory-Induced

  • Epilepsy Reflex
Benign Epilepsy With Centrotemporal Spikes

  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08644 MREG Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MREG VGNC VGNC:43362
Rattus norvegicus MREG RGD RGD:1562333
Macaca mulatta MREG VGNC VGNC:74826
Bos taurus MREG VGNC VGNC:31601
Felis catus MREG VGNC VGNC:107583
Mus musculus MREG MGD MGI:2151839
Others MREG NCBI