2. Gene
  3. Mir140 - microRNA 140 Gene

Mir140 - microRNA 140 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn140; mir-140; mmu-mir-140

Gene ID: 387158 | Gene type: ncRNA

About Mir140

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
20466812 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
18762567 MGI
acts upstream of or within myelination IDA
IDA: Inferred from direct assay
20805985 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
24349493 MGI
acts upstream of or within ossification IDA
IDA: Inferred from direct assay
25751060 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
24349493 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
18723672 MGI
acts upstream of or within sensory perception of sound IEP
IEP: Inferred from expression pattern
23646144 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
20466812 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
20466812 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RISC complex IDA
IDA: Inferred from direct assay
23185045 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00273 hsa-miR-140-5p mimic 96.0% Unkown
HY-R00272 hsa-miR-140-3p mimic 99.20% Unkown
HY-R00273A hsa-miR-140-5p agomir 98.33% Unkown
HY-RI00272 hsa-miR-140-3p inhibitor / Unkown
HY-RI00273A hsa-miR-140-5p antagomir 91.48% Unkown
HY-R00272A hsa-miR-140-3p agomir / Unkown
HY-RI00272A hsa-miR-140-3p antagomir / Unkown
HY-RI00273 hsa-miR-140-5p inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir140 NCBI NCBI:406932