2. Gene
  3. Mir125a - microRNA 125a Gene

Mir125a - microRNA 125a Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn125a

Gene ID: 387235 | Gene type: ncRNA

About Mir125a

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
22751012 MGI
acts upstream of or within cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18791161 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
19621438 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
18762567 MGI
acts upstream of or within long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
25858512 MGI
acts upstream of or within miRNA-mediated gene silencing by inhibition of translation IDA
IDA: Inferred from direct assay
22751012 MGI
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
19898466 MGI
acts upstream of or within negative regulation of stem cell differentiation IGI
IGI: Inferred from genetic interaction
22751012 MGI
acts upstream of or within negative regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22751012 MGI
acts upstream of or within ossification IDA
IDA: Inferred from direct assay
25751060 MGI
acts upstream of or within regulation of erythrocyte differentiation IDA
IDA: Inferred from direct assay
20660734 MGI
acts upstream of stem cell differentiation IGI
IGI: Inferred from genetic interaction
22751012 MGI
acts upstream of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22751012 MGI
Cellular Component GO Annotation Evidence Reference Source
located in synapse IDA
IDA: Inferred from direct assay
22897173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00164 hsa-miR-125a-5p mimic 94.91% Unkown
HY-RI00164 hsa-miR-125a-5p inhibitor 97.48% Unkown
HY-R00163 hsa-miR-125a-3p mimic / Unkown
HY-R00163A hsa-miR-125a-3p agomir / Unkown
HY-R00164A hsa-miR-125a-5p agomir / Unkown
HY-RI00163 hsa-miR-125a-3p inhibitor / Unkown
HY-RI00163A hsa-miR-125a-3p antagomir / Unkown
HY-RI00164A hsa-miR-125a-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir125a NCBI NCBI:406910