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RNF207 - ring finger protein 207 Gene

Also Known as C1orf188

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 388591

About RNF207

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,206,119-6,221,299 (from NCBI)

This gene has 9 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in heart (RPKM 5.9), prostate (RPKM 3.0) and 24 other tissues.

Summary

Enables HSP70 protein binding activity; chaperone binding activity; and transmembrane transporter binding activity. Involved in positive regulation of delayed rectifier Potassium Channel activity; positive regulation of gene expression; and positive regulation of voltage-gated Potassium Channel activity involved in ventricular cardiac muscle cell action potential repolarization. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RNF207 Products (1)

mRNA	Protein	Name
NM_207396.3	NP_997279.2	RING finger protein 207

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	25281747	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	25281747	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25281747	GOA
acts upstream of positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	25281747	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	25281747	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF207 Protein Structure

zf-C3HC4

zf-B_box

0
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200
300
400
500
600
634 a.a.

Protein Preferred Names	Protein Names
RING finger protein 207

Related Diseases

Diseases	Alias
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Posterior Myocardial Infarction
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12076	RNF207 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF207	VGNC	VGNC:64690
Bos taurus	RNF207	VGNC	VGNC:34048
Canis familiaris	RNF207	VGNC	VGNC:45654
Macaca mulatta	RNF207	VGNC	VGNC:100061
Rattus norvegicus	RNF207	RGD	RGD:1586262
Mus musculus	RNF207	MGD	MGI:2684989
Others	RNF207	NCBI