MFSD2B - MFSD2 lysolipid transporter B, sphingolipid Gene

Also Known as SLC59A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 388931

About MFSD2B

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,010,085-24,026,775 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.9), placenta (RPKM 0.3) and 1 other tissue.

Summary

Enables sphingolipid transporter activity. Involved in lipid transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MFSD2B Products (1)

mRNA Protein Name
NM_001346880.2 NP_001333809.1 sphingosine-1-phosphate transporter MFSD2B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sphingolipid transporter activity IDA
IDA: Inferred from direct assay
29045386 GOA
Biological Process GO Annotation Evidence References Source
involved in lipid transport IDA
IDA: Inferred from direct assay
29045386 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
29563527 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
29045386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFSD2B Protein Structure

MFS_2

MFS_2: MFS/sugar transport protein (44 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
Protein Preferred Names Protein Names

sphingosine-1-phosphate transporter MFSD2B

  • S1P transporter

Related Diseases

Diseases Alias
Seckel Syndrome 1

  • SCKL1

  • Nanocephalic Dwarfism

  • Microcephalic Primordial Dwarfism I

  • Seckel-Type Dwarfism

  • Bird-Headed Dwarfism

  • Sckl

  • Seckel Syndrome, Type 1

  • Seckel Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182375A SLB1122168 free base Inhibitor / Unkown
HY-RS08392 MFSD2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MFSD2B VGNC VGNC:31436
Canis familiaris MFSD2B VGNC VGNC:43201
Macaca mulatta MFSD2B VGNC VGNC:74636
Rattus norvegicus MFSD2B RGD RGD:1561716
Mus musculus MFSD2B MGD MGI:3583946
Felis catus MFSD2B VGNC VGNC:63480
Others MFSD2B NCBI