1. Gene
  2. LHCGR - luteinizing hormone/choriogonadotropin receptor Gene

LHCGR - luteinizing hormone/choriogonadotropin receptor Gene

Homo sapiens

Also known as HHG; LHR; LCGR; LGR2; ULG5; LHRHR; LSH-R; LH/CGR; LH/CG-R

Gene ID: 3973 | Gene type: protein coding

About LHCGR

Cytogenetic location: 2p16.3 Genomic coordinates (GRCh38): 2:48,686,774-48,755,724 (from NCBI)

This gene has 6 transcripts (splice variants), 241 orthologues, 2 paralogues and is associated with 6 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate Adenylate Cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

LHCGR Products(1)

mRNA Protein Name
NM_000233.4 NP_000224.2 lutropin-choriogonadotropic hormone receptor precursor

LHCGR Protein Structure

LRR_5

LRR_5: Leucine rich repeats (6 copies) (62 - 132)

LRR_5

LRR_5: Leucine rich repeats (6 copies) (160 - 240)

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (376 - 623)

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  • 699 a.a.
Protein Preferred Names Protein Names

lutropin-choriogonadotropic hormone receptor

hypergonadotropic hypogonadism

Related Diseases

Diseases Alias
Precocious Puberty, Male-Limited

Testotoxicosis

Familial Male-Limited Precocious Puberty

Leydig Cell Adenoma, Somatic, With Precocious Puberty

FMPP

Familial Testotoxicosis

Sexual Precocity, Familial, Gonadotropin-Independent

Familial Gonadotropin-Independent Male-Limited Sexual Precocity

Male-Limited Precocious Puberty

Pubertas Praecox

Gonadotropin-Independent Familial Sexual Precocity

Testotoxicosis, Familial

Precocious Puberty, Male

Precocious Puberty, Male Limited

Familial Gonadotrophin-Independent Sexual Precocity

Gipp

Gonadotrophin-Independent Precocious Puberty

Precocious Pseudopuberty

Familial Male Precocious Puberty

Precocious Puberty In Males

Puberty, Precocious

Precocious Puberty

Leydig Cell Hypoplasia, Type I

Leydig Cell Agenesis

Luteinizing Hormone Resistance, Female

Leydig Cell Hypoplasia Type I

Leydig Cell Hypoplasia With Male Pseudohermaphroditism

Leydig Cell Hypoplasia With Hypergonadotropic Hypogonadism

46,Xy Disorder Of Sex Development Due To Complete Lh Receptor Inactivation

46,Xy Disorder Of Sex Development Due To Complete Lh Resistance

46,Xy Disorder Of Sex Development Due To Complete Luteinizing Hormone Receptor Inactivation

46,Xy Disorder Of Sex Development Due To Complete Luteinizing Hormone Resistance

46,Xy Dsd Due To Complete Lh Receptor Inactivation

46,Xy Dsd Due To Complete Lh Resistance

46,Xy Dsd Due To Complete Luteinizing Hormone Receptor Inactivation

46,Xy Dsd Due To Complete Luteinizing Hormone Resistance

Leydig Cell Hypoplasia Due To Complete Lh Receptor Inactivation

Leydig Cell Hypoplasia Due To Complete Luteinizing Hormone Receptor Inactivation

Leydig Cell Hypoplasia Due To Complete Luteinizing Hormone Resistance

Leydig Cell Hypoplasia

Hypergonadotropic Hypogonadism, Male, Due To Lhcgr Defect

Leydig Cell Hypoplasia, Complete

Leydig Cell Hypoplasia With Pseudohermaphroditism

Leydig Cell Hypoplasia Due To Complete Lh Resistance

Luteinizing Hormone Resistance

LHR

Female Luteinizing Hormone Resistance

Hypergonadotropic Hypogonadism Male Due To Lhcgr Defect

Leydig Cell Hypoplasia Complete

Leydig Cell Hypoplasia Partial

Leydig Cell Hypoplasia Type Ii

Ovarian Luteinizing Hormone Resistance

Testicular Luteinizing Hormone Resistance

Leydig Cell Hypoplasia, Partial

Leydig Cell Hypoplasia Type Ii

46,Xy Disorder Of Sex Developement Due To Partial Lh Receptor Inactivation

46,Xy Disorder Of Sex Developement Due To Partial Lh Resistance

46,Xy Disorder Of Sex Developement Due To Partial Luteinizing Hormone Resistance

46,Xy Dsd Due To Partial Lh Receptor Inactivation

46,Xy Dsd Due To Partial Lh Resistance

46,Xy Dsd Due To Partial Luteinizing Hormone Resistance

Leydig Cell Hypoplasia Due To Partial Lh Receptor Inactivation

Leydig Cell Hypoplasia Due To Partial Lh Resistance

Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Receptor Inactivation

Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Resistance

Leydig Cell Hypoplasia, Type Ii

Pseudohermaphroditism

Indeterminate Sex And Pseudohermaphroditism

Leydig Cell Hypoplasia

46,Xy Disorder Of Sex Development Due To Lh Resistance Or Lhb Deficiency

46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency

46,Xy Dsd Due To Lh Resistance Or Lhb Deficiency

46,Xy Dsd Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency

46,Xy Disorder Of Sex Development Due To Lh Defects

Lh Resistance Due To Lh Receptor Deactivation

Leydig Cell Agenesis

Male Hypergonadotropic Hypogonadism Due To Lhcgr Defect

Male Pseudohermaphroditism Due To Lh Resistance Or Lhb Deficiency

Male Pseudohermaphroditism Due To Luteinizing Hormone Resistance Or Luteinizing Hormone Beta Subunit Deficiency

Lch

Hypoplasia, Leydig Cell

Precocious Puberty

Familial Precocious Puberty

Idiopathic Sexual Precocity

Sexual Precocity

Puberty Precocious

Cryptogenic Sexual Precocity

Amenorrhea

Absence Of Menstruation

Amenia

Hypogonadism
Infertility
Hypogonadism, Male

Male Hypogonadism

Hypogonadism Male

Testicular Hypogonadism

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis

Gonadal Dysgenesis, 46,Xx

Dysgenesis, Ovarian

Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma

Leydig Cell Tumor

Leydig Cell Neoplasm

Tumor, Leydig Cell

Leydig Cell Tumor, Benign

Ovarian Hyperstimulation Syndrome

OHSS

Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous

Secondary Meig'S Syndrome

Ohss - [Ovarian Hyperstimulation Syndrome]

Hyperstimulation Of Ovaries Nos

Hyperstimulation Of Ovaries Associated With Induced Ovulation

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome

Pcos

Polycystic Ovarian Disease

Polycystic Ovaries

Stein-Leventhal Syndrome

Multicystic Ovaries

Polycystic Ovary

Sclerocystic Ovaries

Sclerocystic Ovary Syndrome

Stein-Leventhal Synd.

Cystic Disease Of Ovaries

Cystic Disease Of Ovary

Pco

Pcod

Sclerocystic Ovarian Degeneration

Polycystic Ovary Syndrome, Susceptibility To

Pcos - [Polycystic Ovary Syndrome]

Polycystic Ovary Nos

Pco - [Polycystic Ovary]

Penis Agenesis

Micropenis

Agenesis Of The Penis

Penis Agenesia

Hypogonadotropic Hypogonadism

Klinefelter Syndrome

Klinefelter'S Syndrome

Xxy Syndrome

Xxy Trisomy

Hypogonadotropism

47, Xxy

Congenital Idiopathic Hypogonadotropic Hypogonadism

Isolated Congenital Gonadotropin Deficiency

47,Xxy Syndrome

47, Xxy Syndrome

Klinefelters Syndrome

Hypogonadism

Klinefelter Syndrome In Males

Klinefelter Syndrome, Unspecified

Klinefelter Syndrome Karyotype 47, Xxy

Hypospadias

Hypospadias Familial

Familial Hypospadias

Lactocele

Galactocele

Galactocoele

Lacteal Cyst

Ovarian Disease

Ovarian Dysfunction

Ovarian Diseases

Ovarian Disorders

Disorder Of Endocrine Ovary

Conn'S Syndrome

Cushing Syndrome

Hyperaldosteronism

Primary Hyperaldosteronism

Hypercortisolism

Primary Aldosteronism

Cushing'S Syndrome

Adrenal Gland Hyperfunction

Conn Syndrome

Hyperadrenalism

Ectopic Acth Syndrome

Hyperadrenocorticism

Cushing Disease

Cushing'S Disease

Adrenal Cortex Adenoma

Corticotroph Pituitary Adenoma

Pituitary Corticotroph Micro-Adenoma

Pituitary-Dependent Cushing Syndrome

Pituitary Acth Hypersecretion

Acth Syndrome, Ectopic

Acth-Secreting Pituitary Adenoma

Adrenal Hyperfunction Resulting From Pituitary Acth Excess

Ectopic Adrenocorticotropic Hormone Syndrome

Nodular Primary Adrenocortical Dysplasia

Pituitary Dependent Cushing Syndrome

Pituitary Cushing Syndrome

Pituitary-Dependant Cushing Syndrome

Pituitary-Dependant Hypercortisolism

Pituitary-Dependant Hypercortisolism Disorder

Aldosteronism Primary

Acth Syndrome Ectopic

Adrenal Cushing'S Syndrome

Adrenal Cortical Adenoma

Cushing Syndrome Nos

Cortisol Hypersecretion

Corticoadrenal Hypersecretion

Cushing Syndrome Secondary To Ectopic Acth-Secretion

Ectopic Cushing Syndrome

Hypercortisolism Due To Nonpituitary Tumour

Ectopic Acth - [Adrenocorticotropic Hormone] Secretion

Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome

Idiopathic Aldosteronism

Aldosteronism

Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia

Primary Aldosteronism Due To Adrenal Hyperplasia

Leiomyomatosis
Blount'S Disease

Blount Disease

Tibia Vara

Osteochondrosis Deformans Tibiae

Osteochondrosis Deformans Tibiae, Familial Infantile Type

Familial Infantile Type Osteochondrosis Deformans Tibiae

Blount-Barber Syndrome

Erlacher-Blount Syndrome

Infantile Tibia Vara

Tibia Vara Blount

Blount Disease, Infantile

Anovulation
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

Myopathy, Centronuclear, 5

CNM5

Centronuclear Myopathy 5

Myopathy, Centronuclear, Type 5

Sex Cord-Gonadal Stromal Tumor

Sex Cord-Gonadal Stromal Tumour

Sex Cord Stromal Tumour

Sex Cord-Stromal Neoplasm

Specialized Gonadal Neoplasm

Specialized Gonadal Tumor

Specialized Gonadal Tumour

Sex Cord-Gonadal Stromal Tumors

Sex Cord-Stromal Tumor

Malignant Testicular Sex Cord-Stromal Tumor

Sex Cord Stromal Tumor Of Testis

Disorder Of Sexual Development

Disorder Of Sex Development

Disorders Of Sex Development

Sex Development Disorder

Sex Differentiation Disease

Dsd

Sex Differentiation Disorders

Complete Androgen Insensitivity Syndrome

Cais

Complete Androgen Resistance Syndrome

Androgen Insensitivity Syndrome Complete

Androgen Insensitivity, Complete

Androgen-Insensitivity Syndrome

Testicular Feminization

Diaphragmatic Eventration
Persistent Mullerian Duct Syndrome

Persistent Müllerian Duct Syndrome

Pmds

Persistent Oviduct Syndrome

Persistent Muellerian Duct Syndrome

Female Genital Ducts In Otherwise Normal Male

Hernia Uteri Inguinale

Persistent Mullerian Duct Syndrome, Types 1 And 2

Persistent Mullerian Derivatives

46,Xy Sex Reversal

Swyer Syndrome

Pure Gonadal Dysgenesis 46,Xy

Gonadal Dysgenesis, Xy Female Type

Gonadal Dysgenesis, 46,Xy

46,Xy Cgd

46,Xy Complete Gonadal Dysgenesis

46,Xy Pure Gonadal Dysgenesis

46 Xy Gonadal Dysgenesis

46, Xy Cgd

46, Xy Complete Gonadal Dysgenesis

46, Xy Pure Gonadal Dysgenesis

Xy Pure Gonadal Dysgenesis

Female With 46,Xy Karyotype

Xy Females

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia

Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency

Congenital Lipoid Adrenal Hyperplasia

Lipoid Cah

Lipoid Adrenal Hyperplasia

Adrenal Hyperplasia 1

Cah

Clah

LCAH

Adrenal Hyperplasia I

Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism

Congenital Adrenal Hyperplasia Lipoid

Adrenal Hyperplasia, Congenital

Congenital Adrenal Hyperplasia, Lipoid

AH1

Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism

Adrenal Hyperplasia Congenital

Hyperplasia, Adrenal, Lipoid, Congenital

Congenital Adrenogenital Disorders Associated With Enzyme Deficiency

Congenital Adrenal Cortical Hyperplasia

Congenital Adrenal Gland Hyperplasia

Congenital Adrenogenital Syndrome

Congenital Hyperadrenocorticism

Congenital Adrenogenitalism

Congenital Female Adrenal Pseudohermaphroditism

Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes

Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus LHCGR VGNC VGNC:81112
Mus musculus LHCGR MGD MGI:96783
Macaca mulatta LHCGR VGNC VGNC:106179
Rattus norvegicus LHCGR RGD RGD:3007
Canis familiaris LHCGR VGNC VGNC:54524