FSHR agonist 1
Based on 1 Customer Validation
FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 1256776-89-2
- Formula: C26H33N3O3S
- Molecular Weight:467.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
pEC50: 7.72 (FSHR)[1]
The binding of FSHR agonist 1 (compound 21f) to the FSHR TMD pocket induces inward movements of TM6 and TM7, which directly results in FSHR activation[1].
FSHR agonist 1 (compound 21f) can activate FSHR, LHCGR and TSHR with highly potency and efficacy, while the activation potency for FSHR is more than 10-fold higher than LHCGR (pEC50 of 6.26) and TSHR (pEC50 of 6.48)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1256776-89-2
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Appearance Solid
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Molecular Weight 467.62
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Formula C26H33N3O3S
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Color White to light yellow
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SMILES
O=C(N(C(C)(C)C)CC)C1=NC(C2=CC=CS2)=C3C4=C(CCN13)C=C(OC)C(OC(C)C)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (106.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1385 mL | 10.6924 mL | 21.3849 mL | 53.4622 mL |
| 5 mM | 0.4277 mL | 2.1385 mL | 4.2770 mL | 10.6924 mL | |
| 10 mM | 0.2138 mL | 1.0692 mL | 2.1385 mL | 5.3462 mL | |
| 15 mM | 0.1426 mL | 0.7128 mL | 1.4257 mL | 3.5641 mL | |
| 20 mM | 0.1069 mL | 0.5346 mL | 1.0692 mL | 2.6731 mL | |
| 25 mM | 0.0855 mL | 0.4277 mL | 0.8554 mL | 2.1385 mL | |
| 30 mM | 0.0713 mL | 0.3564 mL | 0.7128 mL | 1.7821 mL | |
| 40 mM | 0.0535 mL | 0.2673 mL | 0.5346 mL | 1.3366 mL | |
| 50 mM | 0.0428 mL | 0.2138 mL | 0.4277 mL | 1.0692 mL | |
| 60 mM | 0.0356 mL | 0.1782 mL | 0.3564 mL | 0.8910 mL | |
| 80 mM | 0.0267 mL | 0.1337 mL | 0.2673 mL | 0.6683 mL | |
| 100 mM | 0.0214 mL | 0.1069 mL | 0.2138 mL | 0.5346 mL |
FSHR agonist 1 Related Classifications
HY-150210 Related Classifications
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