Iqgap3 - IQ motif containing GTPase activating protein 3 Gene

Also Known as D030034H08

Species: Mus musculus

Gene Type: protein coding

Gene ID: 404710

Summary

Enables small GTPase binding activity. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Located in cell-cell junction; cytoplasm; and lateral plasma membrane. Orthologous to human IQGAP3 (IQ motif containing GTPase activating protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Iqgap3 Products (1)

mRNA	Protein	Name
NM_001033484.1	NP_001028656.1	ras GTPase-activating-like protein IQGAP3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18604197	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	18604197	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within positive regulation of mammary gland epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18604197	MGI
acts upstream of or within regulation of cell size	IMP IMP: Inferred from mutant phenotype	18604197	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	18604197	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18604197	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	18604197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ras GTPase-activating-like protein IQGAP3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06887	IQGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Iqgap3	NCBI	NCBI:128239