IQGAP3 - IQ motif containing GTPase activating protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 128239

About IQGAP3

This gene has 4 transcripts (splice variants), 213 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 5.6), duodenum (RPKM 3.0) and 16 other tissues.

Summary

Enables Calmodulin binding activity and Myosin VI light chain binding activity. Predicted to be involved in regulation of actin Cytoskeleton organization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IQGAP3 Products (1)

mRNA Protein Name
NM_178229.5 NP_839943.3 ras GTPase-activating-like protein IQGAP3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IPI
IPI: Inferred from physical interaction
21299499 GOA
enables myosin VI light chain binding IPI
IPI: Inferred from physical interaction
21299499 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IQGAP3 Protein Structure

CH

CH: Calponin homology (CH) domain (39 - 147)

IQ

IQ: IQ calmodulin-binding motif (734 - 750)

IQ

IQ: IQ calmodulin-binding motif (763 - 780)

IQ

IQ: IQ calmodulin-binding motif (792 - 810)

IQ

IQ: IQ calmodulin-binding motif (823 - 841)

RasGAP

RasGAP: GTPase-activator protein for Ras-like GTPase (1009 - 1220)

RasGAP_C

RasGAP_C: RasGAP C-terminus (1432 - 1555)

  • 0
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  • 1500
  • 1631 a.a.
Protein Preferred Names Protein Names

ras GTPase-activating-like protein IQGAP3

IQGAP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IQGAP3 Q86VI3 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
IQGAP3 Q86VI3 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
IQGAP3 Q86VI3 GSN Homo sapiens P06396
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

IQGAP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89778 IQGAP3 Antibody (YA9122) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Lung Papillary Adenocarcinoma

  • Papillary Lung Adenocarcinoma

  • Papillary Adenocarcinoma Of The Lung
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06887 IQGAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IQGAP3 VGNC VGNC:53495
Bos taurus IQGAP3 VGNC VGNC:30260
Rattus norvegicus IQGAP3 RGD RGD:1305951
Felis catus IQGAP3 VGNC VGNC:62966
Macaca mulatta IQGAP3 VGNC VGNC:73634
Mus musculus IQGAP3 MGD MGI:3028642
Others IQGAP3 NCBI