MIR126 - microRNA 126 Gene
Also Known as MIRN126; mir-126; miRNA126
Species: Homo sapiens
About MIR126
This gene has 1 transcript (splice variant) and 144 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IGI
IGI: Inferred from genetic interaction
|
23437250 | GOA |
| enables mRNA 3'-UTR binding |
IMP
IMP: Inferred from mutant phenotype
|
23437250 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
20619534 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
23437250 | GOA |
| enables mRNA base-pairing translational repressor activity |
IMP
IMP: Inferred from mutant phenotype
|
23437250 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
26646931 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lipoprotein Quantitative Trait Locus |
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| Acute Promyelocytic Leukemia |
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| Asthma |
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| Esophageal Cancer |
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| Lung Cancer |
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| Leukemia, Acute Myeloid |
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| Colorectal Cancer |
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| Breast Cancer |
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| Endometriosis |
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| Non-Alcoholic Fatty Liver Disease |
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| Kidney Cancer |
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| Pancreatitis, Hereditary |
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| Oral Squamous Cell Carcinoma |
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| Intermediate Coronary Syndrome |
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| Nonobstructive Coronary Artery Disease |
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| Limb Ischemia |
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| Bone Cancer |
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| Type 2 Diabetes Mellitus |
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| Arteries, Anomalies Of |
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| Microscopic Colitis |
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| Peripheral Artery Disease |
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| Prostate Cancer |
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| Arteriosclerosis Obliterans |
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| Non-Syndromic X-Linked Intellectual Disability 21 |
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| Arteriosclerosis |
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| Background Diabetic Retinopathy |
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| Microcystic Adenoma |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Hepatocellular Carcinoma |
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| Respiratory System Cancer |
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| Thoracic Cancer |
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| Inherited Metabolic Disorder |
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| Acquired Metabolic Disease |
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| Ovarian Disease |
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| Respiratory System Disease |
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| Carotid Artery Disease |
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| Cerebral Arterial Disease |
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| Aortic Aneurysm |
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| Urinary System Disease |
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| Large Intestine Cancer |
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| Reproductive System Disease |
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| Male Reproductive Organ Cancer |
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| Male Reproductive System Disease |
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| Endocrine System Disease |
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| Aortic Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Retinal Vascular Disease |
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| Pulmonary Embolism |
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| Immune System Disease |
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| Bone Marrow Cancer |
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| Cell Type Benign Neoplasm |
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| Gastrointestinal System Disease |
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| Overnutrition |
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| Sensory System Disease |
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| Intestinal Disease |
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| Intrinsic Cardiomyopathy |
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| Gastrointestinal System Cancer |
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| Lymphatic System Disease |
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| Lymphatic System Cancer |
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| Klatskin'S Tumor |
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| Colonic Disease |
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| Connective Tissue Cancer |
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| Heart Valve Disease |
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| Retinal Disease |
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| Bladder Disease |
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| Extrinsic Cardiomyopathy |
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| Female Reproductive System Disease |
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| Intussusception |
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| Stomach Disease |
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| Autoimmune Disease Of Musculoskeletal System |
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| Central Nervous System Disease |
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| Bone Inflammation Disease |
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| Endocrine Gland Cancer |
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| Bile Duct Adenocarcinoma |
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| Ischemia |
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| Pancreas Disease |
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| Spinal Disease |
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| Bronchial Disease |
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| Malignant Astrocytoma |
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| Bile Duct Cancer |
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| Moyamoya Disease 1 |
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| Integumentary System Disease |
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| Central Nervous System Cancer |
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| Uterine Anomalies |
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| Pulmonary Artery Disease |
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| Endocrine Organ Benign Neoplasm |
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| Myocardial Infarction |
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| Leukocyte Disease |
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| Hyperglycemia |
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| Bile Duct Disease |
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| Autoimmune Disease Of Central Nervous System |
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| Cervix Disease |
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| Aortic Aneurysm, Familial Abdominal, 1 |
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| Hepatoblastoma |
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| Aortic Valve Disease 2 |
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| In Situ Carcinoma |
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| Prostate Disease |
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| Breast Disease |
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| Heart Conduction Disease |
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| Cerebrovascular Disease |
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| Lipid Storage Disease |
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| Mature B-Cell Neoplasm |
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| Fabry Disease |
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| Biliary Tract Disease |
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| Autonomic Nervous System Neoplasm |
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| Microvascular Complications Of Diabetes 5 |
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| Physical Disorder |
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| Ovary Epithelial Cancer |
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| Peripheral Nervous System Neoplasm |
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| Hypertension, Essential |
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| Pre-Eclampsia |
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| Large Cell Carcinoma |
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| Disease Of Mental Health |
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| Disease By Infectious Agent |
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| Cardiovascular System Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Coronary Thrombosis |
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| Capillary Hemangioma |
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| Chronic Fatigue Syndrome |
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| Biliary Tract Cancer |
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| Toxic Encephalopathy |
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| Diabetes Mellitus |
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| Upper Respiratory Tract Disease |
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| Esophageal Disease |
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| Bone Sarcoma |
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| Pleuropulmonary Blastoma |
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| Hematologic Cancer |
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| Oral Cavity Cancer |
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| Peripheral Vascular Disease |
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| Retinitis Pigmentosa 11 |
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| Ischemic Bone Disease |
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| Eye Degenerative Disease |
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| Prediabetes Syndrome |
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| Chromosomal Disease |
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| Pharynx Cancer |
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| Bone Resorption Disease |
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| Nasopharyngeal Disease |
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| Intrahepatic Cholangiocarcinoma |
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| Muscular Disease |
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| Intracranial Berry Aneurysm |
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| Autoimmune Disease Of Gastrointestinal Tract |
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| Lung Large Cell Carcinoma |
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| Peripheral Nervous System Disease |
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| Heart Disease |
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| Cerebral Atherosclerosis |
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| Mesothelioma, Malignant |
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| Bronchiolo-Alveolar Adenocarcinoma |
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| Lipid Metabolism Disorder |
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Bone Remodeling Disease |
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| Adult Respiratory Distress Syndrome |
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| Lung Disease |
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| Connective Tissue Disease |
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| Demyelinating Disease |
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| Thymus Gland Disease |
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| Vascular Disease |
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| Bone Deterioration Disease |
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| Chromosomal Duplication Syndrome |
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| Parathyroid Gland Disease |
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| Thymus Cancer |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Monoclonal Gammopathy Of Uncertain Significance |
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| Nervous System Disease |
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| Bone Disease |
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| Lysosomal Storage Disease |
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| Head And Neck Cancer |
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| Pancreatic Ductal Adenocarcinoma |
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| Retinal Cancer |
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| Brain Cancer |
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| Pulmonary Disease, Chronic Obstructive |
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| Lymphoma, Non-Hodgkin, Familial |
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| Eye Disease |
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| Primary Bacterial Infectious Disease |
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| Blood Protein Disease |
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| Muscle Tissue Disease |
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| Respiratory Failure |
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| Lung Squamous Cell Carcinoma |
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| Rectum Cancer |
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| Ocular Cancer |
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| Stroke, Ischemic |
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| Gallbladder Cancer |
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| Pancreatic Cancer |
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| Amino Acid Metabolic Disorder |
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| Plasma Cell Neoplasm |
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| Colorectal Adenocarcinoma |
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| Gastric Cancer |
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| Immune Deficiency Disease |
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| Chronic Kidney Disease |
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| Lung Cancer Susceptibility 3 |
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| Spinal Cord Disease |
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| Crohn'S Disease |
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| Skin Disease |
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Leukemia, Chronic Myeloid |
|
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| Aortic Valve Disease 1 |
|
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| Motor Neuron Disease |
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| Leukemia, Chronic Lymphocytic |
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| Dilated Cardiomyopathy |
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| Hypertrophic Cardiomyopathy |
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| Amyotrophic Lateral Sclerosis 1 |
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| Leukemia, Acute Lymphoblastic |
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| Alzheimer Disease, Familial, 1 |
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| Myeloma, Multiple |
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| Myelodysplastic Syndrome |
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| Parkinson Disease, Late-Onset |
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| Deficiency Anemia |
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| Myopathy |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR126 | RGD | RGD:2325386 |
| Mus musculus | MIR126 | MGD | MGI:2676811 |