MIR154 - microRNA 154 Gene

Also Known as MIRN154; mir-154

Species: Homo sapiens

Gene Type: ncRNA
Gene ID: 406946

About MIR154

This gene has 1 transcript (splice variant), 21 orthologues and 16 paralogues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mRNA base-pairing translational repressor activity IDA
IDA: Inferred from direct assay
24242044 GOA
Biological Process GO Annotation Evidence References Source
involved in miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
24242044 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases Alias
Miyoshi Muscular Dystrophy 1

  • Miyoshi Myopathy

  • MMD1

  • Miyoshi Distal Myopathy

  • Muscular Dystrophy, Distal, Late-Onset, Autosomal Recessive

  • Miyoshi Myopathy 1

  • Mm

  • Muscular Dystrophy, Distal, Late Onset, Autosomal Recessive

  • Distal Muscular Dystrophy, Miyoshi Type

  • Miyoshi Muscular Dystrophy

  • Mmd

  • Muscular Dystrophy Distal Late-Onset Autosomal Recessive

  • Dystrophy, Muscular, Miyoshi Type 1
Polymyositis

  • Pm - [Polymyositis]
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1

  • Calpainopathy

  • Lgmd2a

  • Muscular Dystrophy, Limb-Girdle, Type 2a

  • Lgmd2

  • Muscular Dystrophy, Pelvofemoral

  • LGMDR1

  • Muscular Dystrophy, Limb-Girdle, Type 2

  • Leyden-Moebius Muscular Dystrophy

  • Limb-Girdle Muscular Dystrophy Type 2a

  • Muscular Dystrophy Limb Girdle Type 2a, Erb Type

  • Limb-Girdle Muscular Dystrophy, Type 2e

  • Limb-Girdle Muscular Dystrophy Type 2

  • Limb-Girdle Muscular Dystrophy Type 2e

  • Beta-Sarcoglycan Limb-Girdle Muscular Dystrophy

  • Lgmd2e

  • Muscular Dystrophy Limb-Girdle With Beta-Sarcoglycan Deficiency

  • Leyden-Moebious Muscular Dystrophy

  • Limb-Girdle Muscular Dystrophy 2a

  • Limb-Girdle Muscular Dystrophy, Type 2a

  • Limb-Girdle Muscular Dystrophy, Type 2s

  • Dystrophy, Muscular, Limb-Girdle, Type 2e

  • Dystrophy, Muscular, Limb-Girdle, Type 2s

  • Muscular Dystrophy, Limb-Girdle, Type 2s

  • Beta-Sarcoglycanopathy
Dermatomyositis

  • Amyopathic Dermatomyositis

  • Dermatopolymyositis

  • Adult Dermatomyositis

  • Polymyositis With Skin Involvement

  • Adult Type Dermatomyositis

  • Petges-Clejat Syndrome
Facioscapulohumeral Muscular Dystrophy 1

  • Facioscapulohumeral Muscular Dystrophy

  • Fshd

  • Landouzy-Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Facioscapulohumeral

  • FSHD1

  • Fshd1a

  • Muscular Dystrophy, Facioscapulohumeral, Type 1a

  • Facioscapulohumeral Muscular Dystrophy Type 1a

  • Fsh Muscular Dystrophy

  • Facioscapulohumeral Muscular Dystrophy 1a

  • Facioscapulohumeral Atrophy

  • Facioscapulohumeral Myopathy

  • Muscular Dystrophy, Facioscapulohumeral, Type 1

  • Facioscapulohumeral Muscular Dystrophy Type 1

  • Landouzy Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Landouzy-Dejerine

  • Fshmd1a

  • Facio-Scapulo-Humeral Dystrophy

  • Facioscapulohumeral Type Progressive Muscular Dystrophy

  • Facioscapuloperoneal Muscular Dystrophy

  • Facioscapulohumeral Dystrophy

  • Fsh Dystrophy

  • Landouzy-Dejerine Dystrophy

  • Landouzy-Dejerine Myopathy

  • Fmd

  • Facioscapulohumeral Muscular Dystrophy-1a

  • Muscular Dystrophy Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral, Type 1

  • Landouzy-Dejerine Disease

  • Landouzy-Déjerine Atrophy

  • Facioscapulohumeral Muscle Dystrophy

  • Fmd - [Facioscapulohumeral Muscular Dystrophy]

  • Fsh - [Facioscapulohumeral Muscular Dystrophy]

  • Fshd - [Facioscapulohumeral Muscular Dystrophy]

  • Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

  • Landouzy-Déjérine Muscular Dystrophy
Nemaline Myopathy

  • Rod Myopathy

  • Nemaline Body Disease

  • Nemaline Rod Myopathy

  • Myopathies, Nemaline

  • Nm

  • Nemaline Rod Disease

  • Rod Body Disease

  • Rod-Body Myopathy

  • Myopathy, Nemaline

  • Congenital Rod Disease

  • Nem

  • Nemaline Bodies

  • Myopathies Nemaline
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Muscular Dystrophy, Duchenne Type

  • Duchenne Muscular Dystrophy

  • DMD

  • Muscular Dystrophy, Duchenne

  • Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type

  • Severe Dystrophinopathy, Duchenne Type

  • Muscular Dystrophy Duchenne

  • Dystrophy, Muscular, Duchenne Type

  • Benign Duchenne Muscular Dystrophy

  • Duchenne Motor Neuron Disease

  • Duchenne Type Dystrophy

  • Duchenne-Griesinger Disease
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Thyroid Gland Cancer

  • Thyroid Gland Carcinoma

  • Malignant Neoplasm Of Thyroid Gland

  • Malignant Tumour Of Thyroid Gland

  • Thyroid Neoplasm

  • Thyroid Neoplasms

  • Neoplasm Of Thyroid Gland

  • Thyroid Gland Neoplasm

  • Head And Neck Cancer, Thyroid

  • Neoplasm Of The Thyroid Gland

  • Cancer Of The Thyroid

  • Primary Malignant Neoplasm Of Thyroglossal Duct

  • Malignant Neoplasm Of Thyroglossal Duct

  • Primary Malignant Neoplasm Of Thyroid Gland

  • Thyroglossal Duct Cancer

  • Toxic Goitre Malignant Tumour

  • Cancerous Goitre
Thyroid Gland Medullary Carcinoma

  • Medullary Thyroid Carcinoma

  • Medullary Carcinoma Of The Thyroid Gland

  • Ultimobranchial Thyroid Tumor

  • Ultimobranchial Thyroid Tumour

  • Thyroid Cancer, Medullary
Ductal Carcinoma In Situ

  • Noninfiltrating Intraductal Carcinoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Laryngeal Disease

  • Laryngeal Diseases
Bone Sarcoma
Respiratory System Cancer
Male Reproductive Organ Cancer

  • Genital Neoplasms, Male

  • Male Genital Cancer

  • Male Genital Neoplasm

  • Male Reproductive System Neoplasm

  • Malignant Neoplasm Of Male Genital Organ

  • Malignant Neoplasm Of Male Genital Organ Or Tract

  • Malignant Neoplasm Of Male Genital Organs

  • Malignant Tumor Of Male Genital Organ

  • Malignant Tumor Of Male Reproductive System

  • Neoplasm Of Male Genital Organ

  • Tumor Of Male Reproductive System
Respiratory System Disease

  • Abnormality Of The Respiratory System

  • Respiration Disorders

  • Respiratory Tract Diseases
Male Reproductive System Disease

  • Genital Diseases, Male

  • Disorder Of Male Reproductive System
Connective Tissue Cancer

  • Neoplasms, Connective Tissue

  • Connective Tissue Neoplasm

  • Mesenchymal Tissue Malignant Neoplasm

  • Neoplasm Of Connective Tissues

  • Tumour Of Connective Tissue
Thyroid Gland Disease

  • Abnormality Of The Thyroid Gland

  • Thyroid Diseases
Malignant Astrocytoma

  • Astrocytic Tumor

  • Astrocytoma Of Brain

  • Astrocytoma Of Cerebrum

  • Astroglioma

  • Cerebral Astrocytoma

  • Astrocytoma
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Connective Tissue Disease

  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-R00313 hsa-miR-154-3p mimic 96.76% Unkown
HY-R00314 hsa-miR-154-5p mimic 96.16% Unkown
HY-R00313A hsa-miR-154-3p agomir / Unkown
HY-R00314A hsa-miR-154-5p agomir / Unkown
HY-RI00313 hsa-miR-154-3p inhibitor / Unkown
HY-RI00313A hsa-miR-154-3p antagomir / Unkown
HY-RI00314 hsa-miR-154-5p inhibitor / Unkown
HY-RI00314A hsa-miR-154-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MIR154 RGD RGD:2325562
Mus musculus MIR154 MGD MGI:2676839