MIR17 - microRNA 17 Gene
Also Known as MIR91; MIRN17; MIRN91; miR-17; miRNA17; miRNA91; MIR17-5p; miR17-3p; hsa-mir-17
Species: Homo sapiens
About MIR17
This gene has 1 transcript (splice variant), 142 orthologues and 4 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
21982160 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
20190813 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
21145484 | GOA |
| enables mRNA base-pairing translational repressor activity |
IMP
IMP: Inferred from mutant phenotype
|
19390056 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
31926946 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| B-Cell Lymphoma |
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| Neuroblastoma |
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| Pulmonary Hypertension |
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| Thyroid Gland Anaplastic Carcinoma |
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| Sezary'S Disease |
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| Leukemia, Chronic Myeloid |
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| Lipoprotein Quantitative Trait Locus |
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| Pancreatic Cancer |
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| Glioma |
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| Diabetes Mellitus |
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| Hepatocellular Carcinoma |
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| Polycystic Kidney Disease |
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| Medulloblastoma |
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| Prostate Cancer |
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| Lung Cancer |
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| Breast Cancer |
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| Hepatitis B |
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| Multiple Sclerosis |
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| Primary Biliary Cholangitis |
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| Diffuse Large B-Cell Lymphoma |
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| Psoriasis |
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| Kidney Cancer |
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| Non-Alcoholic Fatty Liver Disease |
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| Bladder Cancer |
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| Cell Type Benign Neoplasm |
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| Childhood Infratentorial Ependymoma |
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| Large Intestine Cancer |
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| Melanoma |
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| Lymphatic System Cancer |
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| Colorectal Cancer |
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| Osteonecrosis |
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| Malignant Exocrine Pancreas Neoplasm |
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| Colonic Disease |
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| Respiratory System Cancer |
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| Thoracic Cancer |
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| Lymphatic System Disease |
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| Retinal Cancer |
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| Endocrine System Disease |
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| Intestinal Benign Neoplasm |
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| Connective Tissue Cancer |
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| Spinal Disease |
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| Stomach Disease |
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| Gastrointestinal System Disease |
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| Autonomic Nervous System Neoplasm |
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| Peripheral Nervous System Neoplasm |
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| Ovarian Cystadenocarcinoma |
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| Male Reproductive Organ Cancer |
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| Male Reproductive System Disease |
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| Mature B-Cell Neoplasm |
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| Intestinal Disease |
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| Gastrointestinal System Cancer |
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| Reproductive System Disease |
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| Central Nervous System Cancer |
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| Bladder Disease |
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| Gastrointestinal System Benign Neoplasm |
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| Colorectal Adenoma |
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| Bone Structure Disease |
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| Bile Duct Adenocarcinoma |
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| Arteries, Anomalies Of |
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| Limb Ischemia |
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| Heart Septal Defect |
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| Female Reproductive System Disease |
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| Bone Deterioration Disease |
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| Respiratory System Disease |
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| Immune System Disease |
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| Endocrine Gland Cancer |
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| Pleural Cancer |
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| Sensory System Disease |
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| Carbohydrate Metabolic Disorder |
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| Leukocyte Disease |
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| Pancreas Disease |
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| Bone Marrow Cancer |
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| Malignant Astrocytoma |
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| Bile Duct Cancer |
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| Urinary System Disease |
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| Cervix Disease |
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| Bile Duct Disease |
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| Glucose Metabolism Disease |
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| Infratentorial Cancer |
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| Larynx Cancer |
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| Ocular Cancer |
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| Inherited Metabolic Disorder |
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| Oral Cavity Cancer |
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| Tongue Disease |
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| Upper Respiratory Tract Disease |
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| Uterine Anomalies |
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| Thyroid Gland Cancer |
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| Acquired Metabolic Disease |
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| Biliary Tract Disease |
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| Ovary Epithelial Cancer |
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| Bone Cancer |
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| Rectal Benign Neoplasm |
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| Physical Disorder |
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| Retinal Disease |
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| Esophageal Disease |
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| Gallbladder Disease |
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| Ischemic Bone Disease |
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| Ovarian Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Rectum Cancer |
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| Pharynx Cancer |
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| Pleural Disease |
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| Nasopharyngeal Disease |
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| Chromosomal Deletion Syndrome |
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| Corneal Dystrophy, Congenital Stromal |
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| Background Diabetic Retinopathy |
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| Feingold Syndrome 1 |
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| Integumentary System Disease |
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| Aortic Disease |
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| Periodontitis |
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| Degenerative Disc Disease |
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| Overnutrition |
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| Prostate Disease |
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| Colorectal Adenocarcinoma |
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| Laryngeal Disease |
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| Gallbladder Cancer |
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| Biliary Tract Cancer |
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| Bone Inflammation Disease |
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| Ovary Adenocarcinoma |
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| Peripheral Artery Disease |
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| Central Nervous System Disease |
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| Autoimmune Disease Of Musculoskeletal System |
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| Hematologic Cancer |
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| Breast Disease |
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| Retinal Vascular Disease |
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| Intrinsic Cardiomyopathy |
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| Cardiovascular Organ Benign Neoplasm |
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| Intermediate Coronary Syndrome |
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| Mature T-Cell And Nk-Cell Lymphoma |
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| Ischemia |
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| Chromosomal Disease |
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| Lymphoma, Non-Hodgkin, Familial |
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| Bone Sarcoma |
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| Myocardial Infarction |
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| Mantle Cell Lymphoma |
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| Nasopharyngeal Carcinoma |
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| Endometriosis |
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| Head And Neck Cancer |
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| Heart Valve Disease |
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| Ovarian Serous Cystadenocarcinoma |
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| Disease By Infectious Agent |
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| Ventricular Septal Defect |
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| Peripheral Nervous System Disease |
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| Cervical Cancer |
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| Tongue Squamous Cell Carcinoma |
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| Large Cell Carcinoma |
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| Brain Cancer |
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| Aortic Valve Disease 1 |
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| Disease Of Mental Health |
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| Bone Resorption Disease |
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| Lipid Storage Disease |
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| Bronchiolo-Alveolar Adenocarcinoma |
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| Thyroid Gland Disease |
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| Uveal Disease |
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| Thyroid Gland Follicular Carcinoma |
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| Eye Degenerative Disease |
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| Bone Remodeling Disease |
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| Pre-Malignant Neoplasm |
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| Cerebrovascular Disease |
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| Pancreatic Ductal Adenocarcinoma |
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| Aortic Valve Disease 2 |
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| Extrinsic Cardiomyopathy |
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| Connective Tissue Disease |
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| Heart Disease |
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| In Situ Carcinoma |
|
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| Microvascular Complications Of Diabetes 5 |
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| Lung Disease |
|
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| Bone Disease |
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| Cardiovascular System Disease |
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| Bronchial Disease |
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| Intrahepatic Cholangiocarcinoma |
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| Hypertension, Essential |
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| Mouth Disease |
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Nervous System Disease |
|
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| Esophageal Cancer |
|
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| Melanoma, Uveal |
|
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| Eye Disease |
|
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| High Grade Glioma |
|
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| Peripheral T-Cell Lymphoma |
|
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| Endocrine Organ Benign Neoplasm |
|
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| Lynch Syndrome |
|
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| Lung Squamous Cell Carcinoma |
|
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| Leukemia, Chronic Lymphocytic |
|
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| Gastric Cancer |
|
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| Lysosomal Storage Disease |
|
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| Muscular Disease |
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| Plasma Cell Neoplasm |
|
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| Leukemia, Acute Myeloid |
|
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| Renal Cell Carcinoma, Nonpapillary |
|
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| Oral Squamous Cell Carcinoma |
|
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| Lipid Metabolism Disorder |
|
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| Mesothelioma, Malignant |
|
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| Lung Cancer Susceptibility 3 |
|
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| Ovarian Cancer |
|
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| Pulmonary Disease, Chronic Obstructive |
|
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| Leukemia, Acute Lymphoblastic |
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| Interstitial Lung Disease 2 |
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| T-Cell Acute Lymphoblastic Leukemia |
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| Immune Deficiency Disease |
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| Skin Disease |
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| Respiratory Failure |
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| Heart Conduction Disease |
|
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Myeloma, Multiple |
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| Hypertrophic Cardiomyopathy |
|
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| Squamous Cell Carcinoma, Head And Neck |
|
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| Dilated Cardiomyopathy |
|
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| Acute Promyelocytic Leukemia |
|
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| Myelodysplastic Syndrome |
|
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| Alzheimer Disease, Familial, 1 |
|
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| Amyotrophic Lateral Sclerosis 1 |
|
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| Type 2 Diabetes Mellitus |
|
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| Melanoma, Cutaneous Malignant 1 |
|
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| Retinitis Pigmentosa |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR17 | RGD | RGD:2325600 |
| Mus musculus | MIR17 | MGD | MGI:3619065 |