MIR200C - microRNA 200c Gene
Also Known as MIRN200C; mir-200c
Species: Homo sapiens
About MIR200C
This gene has 1 transcript (splice variant), 73 orthologues and 2 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
29373717 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
22522429 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
21224847 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Endometrial Cancer |
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| Renal Cell Carcinoma, Nonpapillary |
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| Ovarian Cancer |
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| Gastric Cancer |
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| Lung Cancer |
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| Breast Cancer |
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| Ovarian Serous Carcinoma |
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| Kidney Cancer |
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| Testicular Germ Cell Tumor |
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| Non-Alcoholic Fatty Liver Disease |
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| Systemic Lupus Erythematosus |
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| Oral Squamous Cell Carcinoma |
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| Melanoma |
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| Colorectal Cancer |
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| Uterine Corpus Cancer |
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| T-Cell Prolymphocytic Leukemia |
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| Mycosis Fungoides |
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| Thoracic Cancer |
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| Hepatocellular Carcinoma |
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| Endometriosis |
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| Malignant Exocrine Pancreas Neoplasm |
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| Female Reproductive System Disease |
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| Uterine Anomalies |
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| Colonic Disease |
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| Large Intestine Cancer |
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| Intestinal Disease |
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| Endocrine System Disease |
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| Respiratory System Cancer |
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| Respiratory System Disease |
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| Reproductive System Disease |
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| Urinary System Disease |
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| Endocrine Gland Cancer |
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| Gastrointestinal System Cancer |
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| Ovarian Disease |
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| Gastrointestinal System Disease |
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| Breast Disease |
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| Prolymphocytic Leukemia |
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| Lipoid Nephrosis |
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| Cardiovascular Organ Benign Neoplasm |
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| Pancreas Disease |
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| Bladder Disease |
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| Immune System Disease |
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| Stomach Disease |
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| Limb Ischemia |
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| Lymphatic System Cancer |
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| Central Nervous System Cancer |
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| Lymphatic System Disease |
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| Pancreatic Ductal Adenocarcinoma |
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| Malignant Astrocytoma |
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| Sezary'S Disease |
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| Cervix Disease |
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| Autoimmune Disease Of Gastrointestinal Tract |
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| Spinal Disease |
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| Inherited Metabolic Disorder |
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| Connective Tissue Cancer |
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| Phenylketonuria |
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| Lung Squamous Cell Carcinoma |
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| Pancreatic Cancer |
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| Hematologic Cancer |
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| Purulent Acute Otitis Media |
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| Connective Tissue Disease |
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| Lung Cancer Susceptibility 3 |
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| Lymphoma, Non-Hodgkin, Familial |
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| Nervous System Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR200C | RGD | RGD:2325553 |
| Mus musculus | MIR200C | MGD | MGI:3618750 |