MIR93 - microRNA 93 Gene
Also Known as MIRN9; MIRN93; miR-93; hsa-mir-93
Species: Homo sapiens
About MIR93
This gene has 1 transcript (splice variant).
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
22556343 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
18728182 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
26646931 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Myeloma, Multiple |
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| Hepatocellular Carcinoma |
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| Gastric Cancer |
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| Lung Cancer |
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| Ovarian Serous Carcinoma |
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| Pancreatic Ductal Adenocarcinoma |
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| Alzheimer Disease, Familial, 1 |
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| Neuroblastoma |
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| Autism Spectrum Disorder |
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| Pituitary Cancer |
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| Colorectal Cancer |
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| Functioning Pituitary Adenoma |
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| Prolactinoma |
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| Nasopharyngeal Disease |
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| Tonsil Cancer |
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| Pharynx Cancer |
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| Oropharynx Cancer |
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| Cell Type Benign Neoplasm |
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| Larynx Cancer |
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| Respiratory System Cancer |
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| Macular Holes |
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| Parenchymatous Neurosyphilis |
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| Ovarian Disease |
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| Acth-Secreting Pituitary Adenoma |
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| Respiratory System Disease |
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| Cervix Disease |
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| Upper Respiratory Tract Disease |
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| Pleural Cancer |
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| Female Reproductive System Disease |
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| Thoracic Cancer |
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| Connective Tissue Cancer |
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| Stomach Disease |
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| Nasopharyngeal Carcinoma |
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| Endocrine Gland Cancer |
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| Endocrine System Disease |
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| Endocrine Organ Benign Neoplasm |
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| Reproductive System Disease |
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| Uterine Anomalies |
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| Gastrointestinal System Cancer |
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| Central Nervous System Cancer |
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| Lymphatic System Disease |
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| Pituitary Gland Disease |
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| Urinary System Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Lymphatic System Cancer |
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| Gastrointestinal System Disease |
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| Malignant Astrocytoma |
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| Bladder Disease |
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| Spinal Disease |
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| Cervical Cancer |
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| Bone Resorption Disease |
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| Male Reproductive Organ Cancer |
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| Laryngeal Disease |
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| Carbohydrate Metabolic Disorder |
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| Male Reproductive System Disease |
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| Glucose Metabolism Disease |
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| Immune System Disease |
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| Large Intestine Cancer |
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| Bone Remodeling Disease |
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| Inherited Metabolic Disorder |
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| Intestinal Disease |
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| Pleural Disease |
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| Bone Cancer |
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| Sensory System Disease |
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| Osteoporosis |
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| Breast Disease |
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| Disease By Infectious Agent |
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| Esophageal Disease |
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| Brain Glioma |
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| Oral Cavity Cancer |
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| Head And Neck Cancer |
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| Prostate Disease |
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| Central Nervous System Disease |
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| Colonic Disease |
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| Pancreas Disease |
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| Esophageal Cancer |
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| Adrenal Gland Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Acquired Metabolic Disease |
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| Overnutrition |
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| Arteries, Anomalies Of |
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| Hematologic Cancer |
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| Biliary Tract Cancer |
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| Lung Squamous Cell Carcinoma |
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| Primary Bacterial Infectious Disease |
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| Connective Tissue Disease |
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| Integumentary System Disease |
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| Bone Inflammation Disease |
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| Brain Cancer |
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| Nervous System Disease |
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| Oral Squamous Cell Carcinoma |
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| Eye Disease |
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| Diffuse Large B-Cell Lymphoma |
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| Lymphoma, Non-Hodgkin, Familial |
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| Leukemia, Acute Myeloid |
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| Lung Cancer Susceptibility 3 |
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| Skin Disease |
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| Breast Cancer |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Type 2 Diabetes Mellitus |
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| Fanconi Anemia, Complementation Group A |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR93 | MGD | MGI:3619439 |
| Rattus norvegicus | MIR93 | RGD | RGD:2325459 |