MAGEA2 - MAGE family member A2 Gene

Also Known as CT1.2; MAGE2; MAGEA2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4101

About MAGEA2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,749,863-152,753,884 (from NCBI)

This gene has 10 transcripts (splice variants), 459 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 2.8).

Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each Other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

MAGEA2 Products (8)

mRNA	Protein	Name
NM_001282501.2	NP_001269430.1	melanoma-associated antigen 2
NM_001282502.1	NP_001269431.1	melanoma-associated antigen 2
NM_001282504.1	NP_001269433.1	melanoma-associated antigen 2
NM_001282505.1	NP_001269434.1	melanoma-associated antigen 2
NM_001386130.2	NP_001373059.1	melanoma-associated antigen 2
NM_005361.3	NP_005352.1	melanoma-associated antigen 2
NM_175742.2	NP_786884.1	melanoma-associated antigen 2
NM_175743.2	NP_786885.1	melanoma-associated antigen 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	16847267	GOA
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	16847267	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16847267	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	20864041	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular senescence	IDA IDA: Inferred from direct assay	22117195	GOA
involved in negative regulation of protein acetylation	IDA IDA: Inferred from direct assay	22117195	GOA
involved in negative regulation of protein sumoylation	IDA IDA: Inferred from direct assay	22117195	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16847267	GOA
involved in positive regulation of ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	20864041	GOA
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	20864041	GOA
involved in signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	16847267	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	22117195	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16847267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
melanoma-associated antigen 2	MAGE-2 antigen

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2269A	MAIT-203 acetate		99.12%	Unkown
HY-P2269	MAIT-203		/	Unkown
HY-RS07967	MAGEA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown