country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MAN1A1 - mannosidase alpha class 1A member 1 Gene

Also Known as MAN9; HUMM3; HUMM9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4121

About MAN1A1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:119,177,205-119,350,605 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 62.7), liver (RPKM 46.9) and 25 other tissues.

Summary

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]

MAN1A1 Products (1)

mRNA	Protein	Name
NM_005907.4	NP_005898.2	mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IMP IMP: Inferred from mutant phenotype	27108681	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	27108681	GOA
involved in mannose trimming involved in glycoprotein ERAD pathway	IDA IDA: Inferred from direct assay	27108681	GOA
involved in protein targeting to ER	IMP IMP: Inferred from mutant phenotype	27108681	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	27108681	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAN1A1 Protein Structure

Glyco_hydro_47

0
100
200
300
400
500
600
653 a.a.

Protein Preferred Names	Protein Names
mannosyl-oligosaccharide 1,2-alpha-mannosidase IA	Man9-mannosidase

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70304	Mannosyl-oligosaccharide 1,2-α-mannosidase IA		/	Unkown
HY-RS08004	MAN1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08006	MAN1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08007	MAN1C1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19789	Man1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26285	Man1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAN1A1	MGD	MGI:104677
Bos taurus	MAN1A1	VGNC	VGNC:31161
Felis catus	MAN1A1	VGNC	VGNC:68144
Canis familiaris	MAN1A1	VGNC	VGNC:42942
Rattus norvegicus	MAN1A1	RGD	RGD:1310891
Macaca mulatta	MAN1A1	VGNC	VGNC:74483
Others	MAN1A1	NCBI