Trim63 - tripartite motif-containing 63 Gene

Also Known as RF1; MuRF1; Rnf28

Species: Mus musculus

Gene Type: protein coding
Gene ID: 433766

Summary

Enables ubiquitin protein Ligase activity. Involved in protein monoubiquitination and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within cellular response to dexamethasone stimulus; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Predicted to be located in contractile fiber. Predicted to be active in cytoplasm. Is expressed in embryo and heart. Orthologous to human TRIM63 (tripartite motif containing 63). [provided by Alliance of Genome Resources, Apr 2022]

Trim63 Products (2)

mRNA Protein Name
NM_001039048.2 NP_001034137.2 E3 ubiquitin-protein ligase TRIM63 isoform 1
NM_001369245.1 NP_001356174.1 E3 ubiquitin-protein ligase TRIM63 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15601779 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
15601779 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
23752591 MGI
acts upstream of or within myotube cell development IMP
IMP: Inferred from mutant phenotype
31391242 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15601779 MGI
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
26862156 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19850579 MGI
involved in response to denervation involved in regulation of muscle adaptation IDA
IDA: Inferred from direct assay
21465538 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
31391242 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM63

  • MURF-1

  • RING-type E3 ubiquitin transferase TRIM63

  • muscle ring finger protein 1

  • muscle-specific RING finger protein 1

  • ring finger protein 28

  • tripartite motif-containing protein 63

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15063 TRIM63 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim63 NCBI NCBI:84676