Vash1 - vasohibin 1 Gene

Predicted to enable actin binding activity and metallocarboxypeptidase activity. Predicted to be involved in negative regulation of blood vessel endothelial cell migration; proteolysis; and regulation of angiogenesis. Predicted to act upstream of or within several processes, including blood vessel development; negative regulation of endothelial cell migration; and negative regulation of lymphangiogenesis. Predicted to be located in apical part of cell; endoplasmic reticulum; and extracellular space. Predicted to be active in cytoplasm. Biomarker of portal hypertension. Human ortholog(s) of this gene implicated in liver cirrhosis and portal hypertension. Orthologous to human VASH1 (vasohibin 1). [provided by Alliance of Genome Resources, Apr 2022]