VASH1 - vasohibin 1 Gene

Also Known as TTCP 1; KIAA1036

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22846

About VASH1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:76,761,468-76,783,015 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 12.0), placenta (RPKM 11.8) and 25 other tissues.

Summary

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Apr 2022]

VASH1 Products (1)

mRNA	Protein	Name
NM_014909.5	NP_055724.1	tubulinyl-Tyr carboxypeptidase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	29146869	GOA
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	29146869	GOA
enables metallocarboxypeptidase activity	IMP IMP: Inferred from mutant phenotype	31171830	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	15467828	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	15467828	GOA
acts upstream of or within negative regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	20133819	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	15467828	GOA
acts upstream of or within negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19204325	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	15467828	GOA
acts upstream of or within negative regulation of lymphangiogenesis	IGI IGI: Inferred from genetic interaction	20133819	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	29146869	GOA
acts upstream of or within regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	23056314	GOA
acts upstream of or within response to wounding	IDA IDA: Inferred from direct assay	23056314	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	20736312	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15467828	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15467828	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	15467828	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASH1 Protein Structure

Vasohibin

0
100
200
300
365 a.a.

Protein Preferred Names	Protein Names
tubulinyl-Tyr carboxypeptidase 1	tubulin carboxypeptidase 1

VASH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VASH1	Q7L8A9	DHPS	Homo sapiens	P49366	Validated Y2H	25416956
Intra	VASH1	Q7L8A9	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	25416956
Intra	VASH1	Q7L8A9	DHPS	Homo sapiens	P49366	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Portal Hypertension	Hypertension, Portal Hypertension Portal Pht - [Portal Hypertension] Portal Htn
Myasthenic Syndrome, Congenital, 14	Congenital Myasthenic Syndrome 14 CMS14 Cmsta3 Myasthenic Syndrome, Congenital, With Tubular Aggregates 3 Myasthenic Syndrome, Congenital, 14, With Tubular Aggregates Congenital Myasthenic Syndrome 14, With Tubular Aggregates Congenital Myasthenic Syndrome With Tubular Aggregates 3 Myasthenic Syndrome, Congenital, With Tubular Aggregates, 3 Myasthenic Syndrome, Congenital, Type 14, With Tubular Aggregates

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148542	EpoY		98.8%	Unkown
HY-RS15606	VASH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VASH1	VGNC	VGNC:48233
Mus musculus	VASH1	MGD	MGI:2442543
Macaca mulatta	VASH1	VGNC	VGNC:79213
Felis catus	VASH1	VGNC	VGNC:80810
Rattus norvegicus	VASH1	RGD	RGD:1564082
Bos taurus	VASH1	VGNC	VGNC:36767
Others	VASH1	NCBI