Cacnb1 - calcium voltage-gated channel auxiliary subunit beta 1 Gene

Rattus norvegicus

Also known as CAB1

Gene ID: 50688 | Gene type: protein coding

About Cacnb1

Summary

Enables several functions, including identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to voltage-gated Calcium Channel activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; neuromuscular junction development; and regulation of calcium ion transmembrane transport. Predicted to act upstream of or within calcium ion transport and protein targeting to membrane. Part of voltage-gated Calcium Channel complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb1 Products(1)

mRNA	Protein	Name
NM_017346.2	NP_059042.2	voltage-dependent L-type calcium channel subunit beta-1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18776052	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	19840220	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16049174	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19840220	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	18205403	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19840220	RGD
contributes to voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	16049183	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19996312	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19996312	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	19996312	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	19996312	RGD
part of voltage-gated calcium channel complex	IDA IDA: Inferred from direct assay	16049183	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-dependent L-type calcium channel subunit beta-1

brain calcium channel beta 1 subunit	calcium channel beta 1 subunit
calcium channel voltage-dependent subunit beta 1	calcium channel, voltage-dependent, beta 1 subunit

Cacnb1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cacnb1	P54283	Cacnb1	Rattus norvegicus	P54283	GMS	18776052
Intra	Cacnb1	P54283	Cacnb1	Rattus norvegicus	P54283	Density Sedimentation	18776052

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01805	CACNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cacnb1	NCBI	NCBI:782

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