Fbh1 - F-box DNA helicase 1 Gene

Also Known as Fbx18; Fbxo18

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50755

Summary

Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination; replication fork processing; and replication fork protection. Acts upstream of or within negative regulation of chromatin binding activity and response to intra-S DNA damage checkpoint signaling. Predicted to be located in chromatin and nucleus. Predicted to be part of SCF ubiquitin Ligase complex. Orthologous to human FBH1 (F-box DNA helicase 1). [provided by Alliance of Genome Resources, Apr 2022]

Fbh1 Products (5)

mRNA Protein Name
NM_001348234.1 NP_001335163.1 F-box DNA helicase 1 isoform 2
NM_001348235.1 NP_001335164.1 F-box DNA helicase 1 isoform 2
NM_001348236.1 NP_001335165.1 F-box DNA helicase 1 isoform 2
NM_001348237.1 NP_001335166.1 F-box DNA helicase 1 isoform 2
NM_015792.2 NP_056607.1 F-box DNA helicase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24108124 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
24108124 MGI
involved in negative regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
24108124 MGI
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
24108124 MGI
acts upstream of or within response to intra-S DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
23361013 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box DNA helicase 1

  • F-box only protein 18

  • F-box protein 18

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04768 FBH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbh1 NCBI NCBI:84893