CLEC4A - C-type lectin domain family 4 member A Gene

Also Known as DCIR; LLIR; CD367; DDB27; hDCIR; CLECSF6; HDCGC13P

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50856

About CLEC4A

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,102,907-8,138,607 (from NCBI)

This gene has 5 transcripts (splice variants), 890 orthologues and 14 paralogues. Broad expression in appendix (RPKM 5.2), bone marrow (RPKM 2.2) and 20 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC4A Products (4)

mRNA Protein Name
NM_016184.4 NP_057268.1 C-type lectin domain family 4 member A isoform 1
NM_194447.3 NP_919429.2 C-type lectin domain family 4 member A isoform 3
NM_194448.3 NP_919430.1 C-type lectin domain family 4 member A isoform 4
NM_194450.3 NP_919432.1 C-type lectin domain family 4 member A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables D-mannose binding IDA
IDA: Inferred from direct assay
27015765 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
27015765 GOA
enables carbohydrate binding IDA
IDA: Inferred from direct assay
27015765 GOA
Biological Process GO Annotation Evidence References Source
involved in CD8-positive, alpha-beta T cell activation IDA
IDA: Inferred from direct assay
20530286 GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
IDA: Inferred from direct assay
20530286 GOA
involved in negative regulation of cytokine production IDA
IDA: Inferred from direct assay
18258799 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
18258799 GOA
involved in plasmacytoid dendritic cell antigen processing and presentation IDA
IDA: Inferred from direct assay
18258799 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC4A Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (124 - 232)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member A

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6

Recombinant CLEC4A Proteins

Cat. No. Product Name Accession Purity
HY-P76833 CD367/CLEC4A Protein, Human (HEK293, His) Q9UMR7-1 (Q70-L237) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Vascular Disease

  • Vascular Diseases

  • Aneurysm

  • Spinal Cord Ischemia

  • Vascular Anomaly

  • Spinal Cord Vascular Diseases

  • Vascular Tissue Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02791 CLEC4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24391 Clec4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CLEC4A VGNC VGNC:71170
Rattus norvegicus CLEC4A RGD RGD:1359528
Bos taurus CLEC4A VGNC VGNC:27430
Others CLEC4A NCBI