CLEC4A - C-type lectin domain family 4 member A Gene

Homo sapiens

Also known as DCIR; LLIR; CD367; DDB27; hDCIR; CLECSF6; HDCGC13P

Gene ID: 50856 | Gene type: protein coding

About CLEC4A

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,102,907-8,138,607 (from NCBI)

This gene has 5 transcripts (splice variants), 890 orthologues and 14 paralogues. Broad expression in appendix (RPKM 5.2), bone marrow (RPKM 2.2) and 20 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC4A Products(4)

mRNA	Protein	Name
NM_016184.4	NP_057268.1	C-type lectin domain family 4 member A isoform 1
NM_194447.3	NP_919429.2	C-type lectin domain family 4 member A isoform 3
NM_194448.3	NP_919430.1	C-type lectin domain family 4 member A isoform 4
NM_194450.3	NP_919432.1	C-type lectin domain family 4 member A isoform 2

CLEC4A Protein Structure

Lectin_C

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member A

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6

Recombinant CLEC4A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76833	CD367/CLEC4A Protein, Human (HEK293, His)	Q9UMR7-1 (Q70-L237)	≥95%

Related Diseases

Diseases

Alias

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02791	CLEC4A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLEC4A	VGNC	VGNC:71170
Rattus norvegicus	CLEC4A	RGD	RGD:1359528
Bos taurus	CLEC4A	VGNC	VGNC:27430
Mus musculus	CLEC4A	NCBI
Others	CLEC4A	NCBI

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