GLTP - glycolipid transfer protein Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51228

About GLTP

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,850,945-109,880,541 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues and 5 paralogues. Broad expression in esophagus (RPKM 87.8), skin (RPKM 85.1) and 23 other tissues.

Summary

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

GLTP Products (1)

mRNA	Protein	Name
NM_016433.4	NP_057517.1	glycolipid transfer protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycolipid binding	IDA IDA: Inferred from direct assay	15287756	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22078563	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	15901739	GOA
enables lipid transfer activity	IDA IDA: Inferred from direct assay	15901739	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intermembrane lipid transfer	IDA IDA: Inferred from direct assay	15901739	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	15901739	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLTP Protein Structure

GLTP

0
100
209 a.a.

Protein Preferred Names	Protein Names
glycolipid transfer protein

GLTP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GLTP	Q9NZD2	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	GLTP	Q9NZD2	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	GLTP	Q9NZD2	q8cl89_yerpe	Yersinia pestis	Q8CL89	Y2H Pooling	20711500
Intra	GLTP	Q9NZD2	GLTP	Homo sapiens	Q9NZD2	X-Ray Diffraction	22078563
Intra	GLTP	Q9NZD2	ASPSCR1	Homo sapiens	Q9BZE9	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	SHKBP1	Homo sapiens	Q8TBC3	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	AMD1	Homo sapiens	P17707	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	SHKBP1	Homo sapiens	Q8TBC3	Anti Tag CoIP	28514442
Intra	GLTP	Q9NZD2	AMD1	Homo sapiens	P17707	Anti Tag CoIP	28514442
Intra	GLTP	Q9NZD2	ASPSCR1	Homo sapiens	Q9BZE9-2	Anti Tag CoIP	28514442
Intra	GLTP	Q9NZD2	STARD7	Homo sapiens	Q9NQZ5	Anti Tag CoIP	33961781
Intra	GLTP	Q9NZD2	GLTP	Homo sapiens	Q9NZD2	DLS	22078563
Intra	GLTP	Q9NZD2	STARD7	Homo sapiens	Q9NQZ5	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
D-Bifunctional Protein Deficiency	Bifunctional Peroxisomal Enzyme Deficiency 17-Beta-Hydroxysteroid Dehydrogenase Iv Deficiency Dbp Deficiency Peroxisomal Bifunctional Enzyme Deficiency Pbfe Deficiency Bifunctional Enzyme Deficiency Pseudo-Zellweger Syndrome Zellweger-Like Syndrome DBPD Protein Deficiency, D-Bifunctional
Spondylocarpotarsal Synostosis Syndrome	SCT Spondylocarpotarsal Syndrome Vertebral Fusion With Carpal Coalition Congenital Scoliosis With Unilateral Unsegmented Bar Congenital Synspondylism Spondylocarpotarsal Synostosis Synspondylism, Congenital Scoliosis, Congenital, With Unilateral Unsegmented Bar Scoliosis, Congenital With Unilateral Unsegmented Bar Synspondylism Congenital Sct Syndrome Synspondylism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05506	GLTP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18763	Gltp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25250	Gltp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GLTP	VGNC	VGNC:62599
Bos taurus	GLTP	VGNC	VGNC:50097
Mus musculus	GLTP	MGD	MGI:1929253
Macaca mulatta	GLTP	VGNC	VGNC:108345
Rattus norvegicus	GLTP	RGD	RGD:1564442
Others	GLTP	NCBI