PLA1A - phospholipase A1 member A Gene

Also Known as PSPLA1; PS-PLA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51365

About PLA1A

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,597,885-119,629,811 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 9 paralogues. Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues.

Summary

The protein encoded by this gene is a Phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

PLA1A Products (4)

mRNA Protein Name
NM_001206960.2 NP_001193889.1 phospholipase A1 member A isoform 2 precursor
NM_001206961.2 NP_001193890.1 phospholipase A1 member A isoform 3
NM_001293225.2 NP_001280154.1 phospholipase A1 member A isoform 4
NM_015900.4 NP_056984.1 phospholipase A1 member A isoform 1 precursor

PLA1A Protein Structure

Lipase

Lipase: Lipase (17 - 336)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

phospholipase A1 member A

  • phosphatidylserine-specific phospholipase A1alpha

Related Diseases

Diseases Alias
Orofacial Cleft 8

  • OFC8

  • Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8

  • Non-Syndromic Cleft Lip/Palate 8

  • Non-Syndromic Cleft Lip With Or Without Cleft Palate 8

  • Orofacial Cleft, Type 8
Powassan Encephalitis

  • Powassan Encephalitis Virus Infection
Familial Woolly Hair Syndrome

  • Wooly Hair

  • Familial Wooly Hair Syndrome

  • Hereditary Woolly Hair Syndrome

  • Hereditary Wooly Hair Syndrome

  • Woolly Hair

  • Syndrome With Woolly Hair

  • Wooly Hair Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21024 Pla1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10615 PLA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17852 Lypla1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24321 Lypla1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27541 Pla1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLA1A RGD RGD:621261
Bos taurus PLA1A VGNC VGNC:32953
Canis familiaris PLA1A VGNC VGNC:44619
Macaca mulatta PLA1A VGNC VGNC:76051
Mus musculus PLA1A MGD MGI:1934677
Others PLA1A NCBI