RTF2 - replication termination factor 2 Gene

Also Known as CDAO5; RTFDC1; HSPC164; C20orf43; SHUJUN-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51507

About RTF2

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 40.3), bone marrow (RPKM 39.0) and 25 other tissues.

Summary

Enables DNA binding activity. Involved in cellular response to hydroxyurea and regulation of DNA stability. Located in replication fork. [provided by Alliance of Genome Resources, Apr 2022]

RTF2 Products (4)

mRNA Protein Name
NM_001283035.2 NP_001269964.1 replication termination factor 2 isoform a
NM_001283036.2 NP_001269965.1 replication termination factor 2 isoform c
NM_001283037.2 NP_001269966.1 replication termination factor 2 isoform d
NM_016407.5 NP_057491.2 replication termination factor 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
29290612 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29290612 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydroxyurea IMP
IMP: Inferred from mutant phenotype
29290612 GOA
involved in regulation of DNA stability IMP
IMP: Inferred from mutant phenotype
29290612 GOA
Cellular Component GO Annotation Evidence References Source
located in replication fork IDA
IDA: Inferred from direct assay
29290612 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTF2 Protein Structure

Rtf2

Rtf2: Rtf2 RING-finger (1 - 319)

  • 0
  • 100
  • 200
  • 300
  • 336 a.a.
Protein Preferred Names Protein Names

replication termination factor 2

  • UPF0549 protein C20orf43

RTF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RTF2 Q9BY42 FLNC Homo sapiens Q14315
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 7

  • ALS7

  • Amyotrophic Lateral Sclerosis Type 7
Trichosporonosis
Retinitis Pigmentosa 39

  • RP39

  • Retinitis Pigmentosa, Type 39
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12319 RTF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RTF2 VGNC VGNC:45788
Rattus norvegicus RTF2 RGD RGD:1311072
Bos taurus RTF2 VGNC VGNC:34196
Mus musculus RTF2 MGD MGI:1913654
Macaca mulatta RTF2 VGNC VGNC:77018
Others RTF2 NCBI