Cntnap1 - contactin associated protein-like 1 Gene

Also Known as shm; NCP1; p190; Caspr; Nrxn4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53321

Summary

Predicted to enable SH3 domain binding activity. Involved in several processes, including cell-cell junction organization; neuronal action potential propagation; and synapse organization. Acts upstream of or within neuron projection development. Located in paranode region of axon and septate junction. Is expressed in optic nerve; sciatic nerve; and spinal cord. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human CNTNAP1 (contactin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Cntnap1 Products (2)

mRNA Protein Name
NM_016782.2 NP_058062.2 contactin-associated protein 1 precursor
NM_016782.2 NP_058062.2 contactin-associated protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21632923 MGI
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
28370195 MGI
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
16551741 MGI
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
28370195 MGI
involved in myelination IGI
IGI: Inferred from genetic interaction
31641127 MGI
involved in neuromuscular junction development, skeletal muscle fiber IMP
IMP: Inferred from mutant phenotype
28370195 MGI
involved in neuromuscular process IMP
IMP: Inferred from mutant phenotype
28370195 MGI
involved in neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
16551741 MGI
involved in neuromuscular process controlling posture IMP
IMP: Inferred from mutant phenotype
19816196 MGI
acts upstream of or within neuron projection development IGI
IGI: Inferred from genetic interaction
19458237 MGI
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
16551741 MGI
involved in neuronal action potential propagation IMP
IMP: Inferred from mutant phenotype
19816196 MGI
involved in paranodal junction assembly IMP
IMP: Inferred from mutant phenotype
16551741 MGI
involved in paranodal junction maintenance IMP
IMP: Inferred from mutant phenotype
16687515 MGI
involved in postsynaptic density organization IMP
IMP: Inferred from mutant phenotype
28370195 MGI
involved in protein localization to juxtaparanode region of axon IMP
IMP: Inferred from mutant phenotype
25378149 MGI
involved in protein localization to paranode region of axon IMP
IMP: Inferred from mutant phenotype
16551741 MGI
involved in regulation of synapse maturation IDA
IDA: Inferred from direct assay
33148880 MGI
involved in regulation of synapse maturation IMP
IMP: Inferred from mutant phenotype
33148880 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
33148880 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
33148880 MGI
located in paranode region of axon IDA
IDA: Inferred from direct assay
12975355 MGI
located in septate junction IDA
IDA: Inferred from direct assay
27583434 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

contactin-associated protein 1

  • MHDNIV

  • caspr1

  • neurexin 4 (contactin associated protein)

  • neurexin IV

  • neurexin-4

  • paranodin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02932 CNTNAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cntnap1 NCBI NCBI:8506