Cntnap1 - contactin associated protein-like 1 Gene

Mus musculus

Also known as shm; NCP1; p190; Caspr; Nrxn4

Gene ID: 53321 | Gene type: protein coding

About Cntnap1

Summary

Predicted to enable SH3 domain binding activity. Involved in several processes, including cell-cell junction organization; neuronal action potential propagation; and synapse organization. Acts upstream of or within neuron projection development. Located in paranode region of axon and septate junction. Is expressed in optic nerve; sciatic nerve; and spinal cord. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human CNTNAP1 (contactin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Cntnap1 Products(2)

mRNA	Protein	Name
NM_016782.2	NP_058062.2	contactin-associated protein 1 precursor
NM_016782.2	NP_058062.2	contactin-associated protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21632923	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	28370195	MGI
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16551741	MGI
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	28370195	MGI
involved in myelination	IGI IGI: Inferred from genetic interaction	31641127	MGI
involved in neuromuscular junction development, skeletal muscle fiber	IMP IMP: Inferred from mutant phenotype	28370195	MGI
involved in neuromuscular process	IMP IMP: Inferred from mutant phenotype	28370195	MGI
involved in neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	16551741	MGI
involved in neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	19816196	MGI
acts upstream of or within neuron projection development	IGI IGI: Inferred from genetic interaction	19458237	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	16551741	MGI
involved in neuronal action potential propagation	IMP IMP: Inferred from mutant phenotype	19816196	MGI
involved in paranodal junction assembly	IMP IMP: Inferred from mutant phenotype	16551741	MGI
involved in paranodal junction maintenance	IMP IMP: Inferred from mutant phenotype	16687515	MGI
involved in postsynaptic density organization	IMP IMP: Inferred from mutant phenotype	28370195	MGI
involved in protein localization to juxtaparanode region of axon	IMP IMP: Inferred from mutant phenotype	25378149	MGI
involved in protein localization to paranode region of axon	IMP IMP: Inferred from mutant phenotype	16551741	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	33148880	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	33148880	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	33148880	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	33148880	MGI
located in paranode region of axon	IDA IDA: Inferred from direct assay	12975355	MGI
located in septate junction	IDA IDA: Inferred from direct assay	27583434	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

contactin-associated protein 1

MHDNIV	caspr1
neurexin 4 (contactin associated protein)	neurexin IV
neurexin-4	paranodin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02932	CNTNAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cntnap1	NCBI	NCBI:8506

Name
Email *

	Sorry, but the email address you supplied was invalid.