Ngef - neuronal guanine nucleotide exchange factor Gene

Also Known as Tims2; ephexin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53972

Summary

Enables Ephrin Receptor binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; negative regulation of dendritic spine morphogenesis; and synapse pruning. Is active in glutamatergic synapse. Is expressed in several structures, including brain; eye; female reproductive system; forelimb; and liver. Orthologous to human NGEF (neuronal guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]

Ngef Products (2)

mRNA Protein Name
NM_001111314.1 NP_001104784.1 ephexin-1 isoform 1
NM_019867.2 NP_063920.2 ephexin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
17143272 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17143272 MGI
Biological Process GO Annotation Evidence References Source
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
17143272 MGI
involved in negative regulation of dendritic spine morphogenesis IDA
IDA: Inferred from direct assay
17143272 MGI
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
17143272 MGI
involved in regulation of synapse pruning IDA
IDA: Inferred from direct assay
17143272 MGI
involved in regulation of synapse pruning IEP
IEP: Inferred from expression pattern
17143272 MGI
involved in regulation of synapse pruning IMP
IMP: Inferred from mutant phenotype
17143272 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17143272 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
17143272 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17143272 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephexin-1

  • eph-interacting exchange protein

  • transforming immortalised mammary epithelial sequence 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09276 NGEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ngef NCBI NCBI:25791