Rabep1 - rabaptin, RAB GTPase binding effector protein 1 Gene

Mus musculus

Also known as Rab5ep; rabaptin-5; rabaptin-5alpha

Gene ID: 54189 | Gene type: protein coding

About Rabep1

Summary

Predicted to enable protein domain specific binding activity and protein homodimerization activity. Involved in Golgi to plasma membrane transport and protein localization to ciliary membrane. Located in endosome. Is expressed in brain; embryo; head; lung; and thymus. Orthologous to human RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Rabep1 Products(4)

mRNA	Protein	Name
NM_001291141.1	NP_001278070.1	rab GTPase-binding effector protein 1 isoform 2
NM_001291142.1	NP_001278071.1	rab GTPase-binding effector protein 1 isoform 3
NM_001291143.1	NP_001278072.1	rab GTPase-binding effector protein 1 isoform 4
NM_019400.3	NP_062273.2	rab GTPase-binding effector protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17341663	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane transport	IMP IMP: Inferred from mutant phenotype	25405894	MGI
involved in protein localization to ciliary membrane	IMP IMP: Inferred from mutant phenotype	25405894	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	34564930	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	34564930	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	12890772	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34564930	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	34564930	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rab GTPase-binding effector protein 1

RAB5 effector protein	neurocrescin
rabaptin 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11582	RABEP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rabep1	NCBI	NCBI:9135

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