Pabpn1 - poly(A) binding protein, nuclear 1 Gene

Also Known as PAB2; Pabp3; mPABII

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54196

Summary

Enables RNA polymerase binding activity. Involved in MAPK cascade; cellular response to lipopolysaccharide; and positive regulation of polynucleotide adenylyltransferase activity. Located in nucleus. Part of ribonucleoprotein complex. Is expressed in central nervous system; sensory organ; and thymus. Used to study oculopharyngeal muscular dystrophy. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Apr 2022]

Pabpn1 Products (1)

mRNA Protein Name
NM_019402.2 NP_062275.1 polyadenylate-binding protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase binding IDA
IDA: Inferred from direct assay
22844456 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22844456 MGI
Biological Process GO Annotation Evidence References Source
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
22844456 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
22844456 MGI
involved in positive regulation of polynucleotide adenylyltransferase activity IMP
IMP: Inferred from mutant phenotype
22844456 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22844456 MGI
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
22844456 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyadenylate-binding protein 2

  • PABII

  • PABP-2

  • nuclear poly(A)-binding protein 1

  • poly(A) binding protein II

  • poly(A)-binding protein 2

  • polyadenylate-binding nuclear protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09952 PABPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pabpn1 NCBI NCBI:8106