Eif2s1 - eukaryotic translation initiation factor 2 subunit alpha Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54318

Summary

Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of cell death; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; glial limiting end-foot; and nucleus. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Eif2s1 Products (1)

mRNA Protein Name
NM_019356.1 NP_062229.1 eukaryotic translation initiation factor 2 subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2450747 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to heat IDA
IDA: Inferred from direct assay
7930798 RGD
involved in cellular response to heat IEP
IEP: Inferred from expression pattern
3500171 RGD
involved in negative regulation of guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9582312 RGD
involved in positive regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17158450 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
17251432 RGD
involved in response to manganese-induced endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
23934647 RGD
Cellular Component GO Annotation Evidence References Source
part of eukaryotic translation initiation factor 2 complex IDA
IDA: Inferred from direct assay
2450747 RGD
located in glial limiting end-foot IDA
IDA: Inferred from direct assay
9397028 RGD
part of translation initiation ternary complex IDA
IDA: Inferred from direct assay
2450747 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 2 subunit 1

  • EIF-2A

  • EIF-2alpha

  • eIF-2-alpha

  • eukaryotic translation initiation factor 2 subunit 1 alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04254 EIF2S1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21851 Eif2s1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28368 Eif2s1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2s1 NCBI NCBI:1965