WDR44 - WD repeat domain 44 Gene

Also Known as RPH11; SYM-4; RAB11BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54521

About WDR44

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,346,073-118,449,961 (from NCBI)

This gene has 5 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in gall bladder (RPKM 7.8), testis (RPKM 7.1) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

WDR44 Products (3)

mRNA Protein Name
NM_001184965.2 NP_001171894.1 WD repeat-containing protein 44 isoform 2
NM_001184966.1 NP_001171895.1 WD repeat-containing protein 44 isoform 3
NM_019045.5 NP_061918.3 WD repeat-containing protein 44 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular sequestering activity IMP
IMP: Inferred from mutant phenotype
31204173 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31204173 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
31204173 GOA
Biological Process GO Annotation Evidence References Source
involved in cytosolic ciliogenesis IMP
IMP: Inferred from mutant phenotype
31204173 GOA
involved in negative regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
31204173 GOA
involved in regulation of vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
31204173 GOA
Cellular Component GO Annotation Evidence References Source
is active in endosome membrane IDA
IDA: Inferred from direct assay
32344433 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR44 Protein Structure

WD40

WD40: WD domain, G-beta repeat (508 - 538)

WD40

WD40: WD domain, G-beta repeat (602 - 634)

WD40

WD40: WD domain, G-beta repeat (645 - 676)

WD40

WD40: WD domain, G-beta repeat (793 - 814)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 913 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 44

  • rabphilin-11

WDR44 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR44 Q5JSH3 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
WDR44 Q5JSH3 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
WDR44 Q5JSH3 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15780 WDR44 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus WDR44 VGNC VGNC:67033
Canis familiaris WDR44 VGNC VGNC:48368
Rattus norvegicus WDR44 RGD RGD:727965
Bos taurus WDR44 VGNC VGNC:36900
Mus musculus WDR44 MGD MGI:1919654
Macaca mulatta WDR44 VGNC VGNC:79853