SHLD2 - shieldin complex subunit 2 Gene

Also Known as RINN2; FAM35A; FAM35A1; bA163M19.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54537

About SHLD2

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:87,094,473-87,191,465 (from NCBI)

This gene has 3 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in kidney (RPKM 20.9), thyroid (RPKM 14.9) and 25 other tissues.

Summary

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in nucleus and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SHLD2 Products (17)

mRNA Protein Name
NM_001330112.2 NP_001317041.1 shieldin complex subunit 2 isoform 1
NM_001377158.1 NP_001364087.1 shieldin complex subunit 2 isoform 2
NM_001377159.1 NP_001364088.1 shieldin complex subunit 2 isoform 2
NM_001377160.1 NP_001364089.1 shieldin complex subunit 2 isoform 3
NM_001377161.1 NP_001364090.1 shieldin complex subunit 2 isoform 4
NM_001377162.1 NP_001364091.1 shieldin complex subunit 2 isoform 5
NM_001377163.1 NP_001364092.1 shieldin complex subunit 2 isoform 6
NM_001377164.1 NP_001364093.1 shieldin complex subunit 2 isoform 7
NM_001377165.1 NP_001364094.1 shieldin complex subunit 2 isoform 7
NM_001377166.1 NP_001364095.1 shieldin complex subunit 2 isoform 8
NM_001377167.1 NP_001364096.1 shieldin complex subunit 2 isoform 8
NM_001377168.1 NP_001364097.1 shieldin complex subunit 2 isoform 8
NM_001377169.1 NP_001364098.1 shieldin complex subunit 2 isoform 9
NM_001377170.1 NP_001364099.1 shieldin complex subunit 2 isoform 10
NM_001377171.1 NP_001364100.1 shieldin complex subunit 2 isoform 11
NM_001377172.1 NP_001364101.1 shieldin complex subunit 2 isoform 12
NM_019054.3 NP_061927.2 shieldin complex subunit 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29656893 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of isotype switching IDA
IDA: Inferred from direct assay
29656893 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
29656893 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29789392 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
29656893 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

shieldin complex subunit 2

  • RINN1-REV7-interacting novel NHEJ regulator 2

SHLD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHLD2 Q86V20 SHLD1 Homo sapiens Q8IYI0
Anti Tag CoIP
29656893
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139289 ART812 99.90% Unkown
HY-158346 RP-2119 Inhibitor 99.94% Unkown
HY-RS12874 SHLD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SHLD2 VGNC VGNC:40677
Felis catus SHLD2 VGNC VGNC:65128
Mus musculus SHLD2 MGD MGI:1922948
Rattus norvegicus SHLD2 RGD RGD:1565067
Bos taurus SHLD2 VGNC VGNC:28808
Macaca mulatta SHLD2 VGNC VGNC:106101
Others SHLD2 NCBI