SHLD1 - shieldin complex subunit 1 Gene

Also Known as RINN3; C20orf196

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 149840

About SHLD1

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,750,193-5,864,395 (from NCBI)

This gene has 4 transcripts (splice variants) and 107 orthologues. Ubiquitous expression in lymph node (RPKM 1.6), adrenal (RPKM 1.1) and 24 other tissues.

Summary

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SHLD1 Products (4)

mRNA Protein Name
NM_001303477.2 NP_001290406.1 shieldin complex subunit 1 isoform 1
NM_001303478.2 NP_001290407.1 shieldin complex subunit 1 isoform 2
NM_001303479.2 NP_001290408.1 shieldin complex subunit 1 isoform 3
NM_152504.4 NP_689717.2 shieldin complex subunit 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29656893 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of isotype switching IDA
IDA: Inferred from direct assay
29656893 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
29656893 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
29656893 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHLD1 Protein Structure

DUF4521

DUF4521: Protein of unknown function (DUF4521) (1 - 204)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

shieldin complex subunit 1

  • RINN1-REV7-interacting novel NHEJ regulator 3

SHLD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHLD1 Q8IYI0 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
SHLD1 Q8IYI0 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
SHLD1 Q8IYI0 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
SHLD1 Q8IYI0 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
SHLD1 Q8IYI0 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
SHLD1 Q8IYI0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
SHLD1 Q8IYI0 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SHLD1 Q8IYI0 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SHLD1 Q8IYI0 WFS1 Homo sapiens O76024
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112210 Shield-1 Modulator 99.55% Unkown
HY-RS12873 SHLD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SHLD1 VGNC VGNC:49170
Canis familiaris SHLD1 VGNC VGNC:52529
Rattus norvegicus SHLD1 RGD RGD:1597982
Felis catus SHLD1 VGNC VGNC:65127
Mus musculus SHLD1 MGD MGI:1920997
Others SHLD1 NCBI