SPATA6 - spermatogenesis associated 6 Gene

Also Known as HASH; SRF1; SRF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54558

About SPATA6

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:48,261,389-48,472,204 (from NCBI)

This gene has 11 transcripts (splice variants), 143 orthologues and 1 paralogue. Broad expression in testis (RPKM 10.6), thyroid (RPKM 2.4) and 19 other tissues.

Summary

Predicted to enable Myosin light chain binding activity. Predicted to be involved in motile cilium assembly and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in sperm connecting piece. [provided by Alliance of Genome Resources, Apr 2022]

SPATA6 Products (3)

mRNA	Protein	Name
NM_001286238.2	NP_001273167.1	spermatogenesis-associated protein 6 isoform 2
NM_001286239.2	NP_001273168.1	spermatogenesis-associated protein 6 isoform 3
NM_019073.4	NP_061946.1	spermatogenesis-associated protein 6 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPATA6 Protein Structure

SPATA6

0
100
200
300
400
488 a.a.

Protein Preferred Names	Protein Names
spermatogenesis-associated protein 6	spermatogenesis-related factor-1

SPATA6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPATA6	Q9NWH7	DDB2	Homo sapiens	Q92466	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spermatogenic Failure 16	SPGF16 Acephalic Spermatozoa Syndrome Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa	Acephalic Spermatozoa Syndrome
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset	EMARDD Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13643	SPATA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPATA6	VGNC	VGNC:77953
Felis catus	SPATA6	VGNC	VGNC:65617
Rattus norvegicus	SPATA6	RGD	RGD:628657
Bos taurus	SPATA6	VGNC	VGNC:35189
Canis familiaris	SPATA6	VGNC	VGNC:46717
Mus musculus	SPATA6	MGD	MGI:1915196
Others	SPATA6	NCBI