FBXL19 - F-box and leucine rich repeat protein 19 Gene

Also Known as Fbl19; CXXC11; JHDM1C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54620

About FBXL19

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,922,851-30,948,783 (from NCBI)

This gene has 8 transcripts (splice variants), 362 orthologues and 15 paralogues. Broad expression in testis (RPKM 9.4), brain (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FBXL19 Products (5)

mRNA	Protein	Name
NM_001099784.3	NP_001093254.2	F-box/LRR-repeat protein 19 isoform 1
NM_001282351.1	NP_001269280.1	F-box/LRR-repeat protein 19 isoform 3
NM_001382779.1	NP_001369708.1	F-box/LRR-repeat protein 19 isoform 4
NM_001382780.1	NP_001369709.1	F-box/LRR-repeat protein 19 isoform 5
NM_001382781.1	NP_001369710.1	F-box/LRR-repeat protein 19 isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22660580	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	22660580	GOA
enables unmethylated CpG binding	IDA IDA: Inferred from direct assay	29276034	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29276034	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22660580	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23512198	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	22660580	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL19 Protein Structure

zf-CXXC

F-box

0
200
400
600
694 a.a.

Protein Preferred Names	Protein Names
F-box/LRR-repeat protein 19	jumonji C domain-containing histone demethylase 1C

FBXL19 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	FBXL19	Q6PCT2	Il1rl1	Mus musculus	P14719	Ubiquitinase Assay	22660580
Cross	FBXL19	Q6PCT2	Il1rl1	Mus musculus	P14719	Pull Down	22660580

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Psoriasis 10	PSORS10 Psoriasis Susceptibility 10 Psoriasis 10, Susceptibility To
Psoriasis 6	PSORS6 Psoriasis Susceptibility 6 Psoriasis 6, Susceptibility To
Psoriasis 2	PSORS2 Psoriasis Psoriasis Vulgaris Pv Psoriasis, Susceptibility To, Type 2
Psoriasis
Psoriasis 3	PSORS3 Psoriasis Susceptibility 3 Psoriasis 3, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04788	FBXL19 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FBXL19	VGNC	VGNC:59170
Canis familiaris	FBXL19	VGNC	VGNC:40759
Rattus norvegicus	FBXL19	RGD	RGD:1310989
Macaca mulatta	FBXL19	VGNC	VGNC:81406
Felis catus	FBXL19	VGNC	VGNC:80573
Mus musculus	FBXL19	MGD	MGI:3039600
Others	FBXL19	NCBI