Sh3glb1 - SH3-domain GRB2-like B1 (endophilin) Gene

Mus musculus

Also known as Bif-1; mKIAA0491

Gene ID: 54673 | Gene type: protein coding

About Sh3glb1

Summary

Enables fatty acid binding activity and lysophosphatidic acid Acyltransferase activity. Involved in several processes, including positive regulation of autophagosome assembly; positive regulation of phosphatidylinositol 3-kinase activity; and regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Acts upstream of or within 'de novo' posttranslational protein folding; phosphatidic acid biosynthetic process; and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. Located in membrane. Part of protein-containing complex. Is expressed in cerebellum; embryo; endolymphatic appendage; otocyst; and spleen. Orthologous to human SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3glb1 Products(8)

mRNA	Protein	Name
NM_001282037.1	NP_001268966.1	endophilin-B1 isoform 1
NM_001282042.1	NP_001268971.1	endophilin-B1 isoform 3
NM_001379170.1	NP_001366099.1	endophilin-B1 isoform 4
NM_001379171.1	NP_001366100.1	endophilin-B1 isoform 5
NM_001379172.1	NP_001366101.1	endophilin-B1 isoform 6
NM_001379173.1	NP_001366102.1	endophilin-B1 isoform 7
NM_001379174.1	NP_001366103.1	endophilin-B1 isoform 8
NM_019464.3	NP_062337.1	endophilin-B1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid binding	IDA IDA: Inferred from direct assay	12456676	MGI
enables lysophosphatidic acid acyltransferase activity	IDA IDA: Inferred from direct assay	12456676	MGI
enables phosphatidylinositol 3-kinase activator activity	IMP IMP: Inferred from mutant phenotype	17891140	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12456676	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within 'de novo' post-translational protein folding	IDA IDA: Inferred from direct assay	16227588	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16227588	MGI
involved in autophagic cell death	IMP IMP: Inferred from mutant phenotype	17891140	MGI
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	24523556	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	24523556	MGI
acts upstream of or within phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	12456676	MGI
acts upstream of or within phospholipid biosynthetic process	IDA IDA: Inferred from direct assay	12456676	MGI
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	21068542	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	17891140	MGI
acts upstream of or within positive regulation of establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	16227588	MGI
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	24523556	MGI
involved in protein localization to vacuolar membrane	IMP IMP: Inferred from mutant phenotype	21068542	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	12456676	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17891140	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endophilin-B1

SH3 domain-containing GRB2-like protein B1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12839	SH3GLB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3glb1	NCBI	NCBI:51100

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