Crtam - cytotoxic and regulatory T cell molecule Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 54698

Summary

Enables signaling receptor binding activity. Involved in several processes, including detection of tumor cell; establishment of T cell polarity; and regulation of T cell activation. Located in immunological synapse. Orthologous to human CRTAM (cytotoxic and regulatory T cell molecule). [provided by Alliance of Genome Resources, Apr 2022]

Crtam Products (2)

mRNA	Protein	Name
NM_001281954.2	NP_001268883.1	cytotoxic and regulatory T-cell molecule isoform 1 precursor
NM_019465.5	NP_062338.3	cytotoxic and regulatory T-cell molecule isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18329370	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15811952	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cell recognition	IDA IDA: Inferred from direct assay	15811952	MGI
involved in detection of stimulus	IDA IDA: Inferred from direct assay	15811952	MGI
involved in detection of tumor cell	IDA IDA: Inferred from direct assay	15811952	MGI
involved in establishment of T cell polarity	IDA IDA: Inferred from direct assay	18329370	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	19752223	MGI
involved in lymphocyte migration into lymphoid organs	IMP IMP: Inferred from mutant phenotype	24687959	MGI
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18329370	MGI
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	15811952	MGI
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA IDA: Inferred from direct assay	15811952	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18329370	MGI
involved in regulation of CD8-positive, alpha-beta T cell activation	IMP IMP: Inferred from mutant phenotype	19752223	MGI
involved in regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	24687959	MGI
involved in regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	24687959	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	18329370	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15811952	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytotoxic and regulatory T-cell molecule	class I-restricted T cell-associated molecule class-I MHC-restricted T-cell-associated molecule

Crtam Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Crtam	Q149L7	Scrib	Mus musculus	Q80U72	Anti Bait CoIP	18329370
Intra	Crtam	Q149L7	Scrib	Mus musculus	Q80U72	Anti Tag CoIP	18329370
Intra	Crtam	Q149L7	Scrib	Mus musculus	Q80U72	Confocal	18329370

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Crtam Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77907	CRTAM/CD355 Protein, Mouse (HEK293, His)	Q149L7-1 (A17-G289)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03198	CRTAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17420	Crtam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23874	Crtam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crtam	NCBI	NCBI:56253