2. Gene
  3. CRTAM - cytotoxic and regulatory T cell molecule Gene

CRTAM - cytotoxic and regulatory T cell molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CD355

Gene ID: 56253 | Gene type: protein coding

About CRTAM

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:122,838,500-122,872,643 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 4.2), spleen (RPKM 1.7) and 11 other tissues.

Summary

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

CRTAM Products(2)

mRNA Protein Name
NM_001304782.2 NP_001291711.1 cytotoxic and regulatory T-cell molecule isoform 2 precursor
NM_019604.4 NP_062550.2 cytotoxic and regulatory T-cell molecule isoform 1 precursor

CRTAM Protein Structure

V-set

V-set: Immunoglobulin V-set domain (20 - 113)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (129 - 206)

  • 0
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  • 393 a.a.
Protein Preferred Names Protein Names

cytotoxic and regulatory T-cell molecule

class-I MHC-restricted T-cell-associated molecule

Recombinant CRTAM Proteins

Cat. No. Product Name Accession Purity
HY-P7855 CRTAM/CD355 Protein, Human (HEK293, His) O95727 (S18-S286) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03198 CRTAM Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRTAM VGNC VGNC:84883
Mus musculus CRTAM MGD MGI:1859822
Bos taurus CRTAM VGNC VGNC:27726
Canis familiaris CRTAM VGNC VGNC:39630
Felis catus CRTAM VGNC VGNC:61190
Rattus norvegicus CRTAM RGD RGD:1304602
Macaca fascicularis CRTAM NCBI
Others CRTAM NCBI