Fezf2 - Fez family zinc finger 2 Gene

Mus musculus

Also known as Fez; Fezl; Zfp312

Gene ID: 54713 | Gene type: protein coding

About Fezf2

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell dedifferentiation; nervous system development; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; future prosencephalon; sensory organ; stomach; and thymus. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Fezf2 Products(1)

mRNA	Protein	Name
NM_080433.3	NP_536681.2	fez family zinc finger protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24997765	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24997765	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20431123	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24997765	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28245922	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	28245922	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of GABAergic neuron differentiation	IDA IDA: Inferred from direct assay	24997765	MGI
acts upstream of or within axonal fasciculation	IMP IMP: Inferred from mutant phenotype	16284245	MGI
involved in cell dedifferentiation	IGI IGI: Inferred from genetic interaction	20152183	MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration	IMP IMP: Inferred from mutant phenotype	21338885	MGI
acts upstream of or within cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	21338885	MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain	IMP IMP: Inferred from mutant phenotype	21338885	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	16314561	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	16971467	MGI
acts upstream of or within forebrain anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16971467	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15188439	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	15188439	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20431123	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	24997765	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20431123	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	20431123	MGI
acts upstream of or within neuron fate determination	IDA IDA: Inferred from direct assay	24997765	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20431123	MGI
acts upstream of or within positive regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	20431123	MGI
acts upstream of or within regulation of axon guidance	IMP IMP: Inferred from mutant phenotype	16284245	MGI
involved in regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	20152183	MGI
acts upstream of or within telencephalon development	IGI IGI: Inferred from genetic interaction	20431123	MGI
involved in telencephalon development	IMP IMP: Inferred from mutant phenotype	20431123	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fez family zinc finger protein 2

forebrain embryonic zinc finger	forebrain embryonic zinc finger-like protein 2
zinc finger protein 312

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04873	FEZF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fezf2	NCBI	NCBI:55079

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