Fezf2 - Fez family zinc finger 2 Gene

Also Known as Fez; Fezl; Zfp312

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54713

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell dedifferentiation; nervous system development; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; future prosencephalon; sensory organ; stomach; and thymus. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Fezf2 Products (1)

mRNA Protein Name
NM_080433.3 NP_536681.2 fez family zinc finger protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
24997765 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
24997765 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20431123 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
24997765 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28245922 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
28245922 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of GABAergic neuron differentiation IDA
IDA: Inferred from direct assay
24997765 MGI
acts upstream of or within axonal fasciculation IMP
IMP: Inferred from mutant phenotype
16284245 MGI
involved in cell dedifferentiation IGI
IGI: Inferred from genetic interaction
20152183 MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration IMP
IMP: Inferred from mutant phenotype
21338885 MGI
acts upstream of or within cerebral cortex neuron differentiation IMP
IMP: Inferred from mutant phenotype
21338885 MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain IMP
IMP: Inferred from mutant phenotype
21338885 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
16314561 MGI
acts upstream of or within dentate gyrus development IMP
IMP: Inferred from mutant phenotype
16971467 MGI
acts upstream of or within forebrain anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16971467 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15188439 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
15188439 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20431123 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
24997765 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20431123 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
20431123 MGI
acts upstream of or within neuron fate determination IDA
IDA: Inferred from direct assay
24997765 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20431123 MGI
acts upstream of or within positive regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
20431123 MGI
acts upstream of or within regulation of axon guidance IMP
IMP: Inferred from mutant phenotype
16284245 MGI
involved in regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
20152183 MGI
acts upstream of or within telencephalon development IGI
IGI: Inferred from genetic interaction
20431123 MGI
involved in telencephalon development IMP
IMP: Inferred from mutant phenotype
20431123 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fez family zinc finger protein 2

  • forebrain embryonic zinc finger

  • forebrain embryonic zinc finger-like protein 2

  • zinc finger protein 312

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04873 FEZF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fezf2 NCBI NCBI:55079