Btnl2 - butyrophilin-like 2 Gene

Also Known as NG9; Btl2; BTLN2; Gm315; BTL-II

Species: Mus musculus

Gene Type: protein coding
Gene ID: 547431

Summary

Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation; and positive regulation of interleukin-2 production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in intestine and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); berylliosis; coronary artery disease; and sarcoidosis. Orthologous to human BTNL2 (butyrophilin like 2). [provided by Alliance of Genome Resources, Apr 2022]

Btnl2 Products (1)

mRNA Protein Name
NM_079835.2 NP_524574.1 butyrophilin-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables signaling receptor binding IDA
IDA: Inferred from direct assay
16751379 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16751379 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

butyrophilin-like protein 2

  • butyrophylin-like MHC class II associated

Recombinant Btnl2 Proteins

Cat. No. Product Name Accession Purity
HY-P7686 BTNL2 Protein, Mouse (HEK293, His) O70355 (D27-S452) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01676 BTNL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20867 Btnl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27382 Btnl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btnl2 NCBI NCBI:56244