RIC8B - RIC8 guanine nucleotide exchange factor B Gene

Also Known as RIC8; hSyn

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55188

About RIC8B

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,774,682-106,889,316 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 2.6), gall bladder (RPKM 2.0) and 25 other tissues.

Summary

Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RIC8B Products (10)

mRNA Protein Name
NM_001330145.2 NP_001317074.1 synembryn-B isoform 1
NM_001330146.2 NP_001317075.1 synembryn-B isoform 2
NM_001330147.2 NP_001317076.1 synembryn-B isoform 3
NM_001351361.2 NP_001338290.1 synembryn-B isoform 5
NM_001351362.2 NP_001338291.1 synembryn-B isoform 6
NM_001351363.2 NP_001338292.1 synembryn-B isoform 7
NM_001351364.2 NP_001338293.1 synembryn-B isoform 8
NM_001351366.2 NP_001338295.1 synembryn-B isoform 9
NM_001351367.2 NP_001338296.1 synembryn-B isoform 10
NM_018157.4 NP_060627.2 synembryn-B isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IDA
IDA: Inferred from direct assay
12652642 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12652642 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
12652642 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12652642 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIC8B Protein Structure

Ric8

Ric8: Guanine nucleotide exchange factor synembryn (66 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

synembryn-B

  • brain synembrin

Related Diseases

Diseases Alias
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

  • Familial Amyloid Neuropathy, Finnish Type

  • Familial Amyloid Polyneuropathy, Type V
Pain Agnosia

  • Analgesia
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11968 RIC8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RIC8B MGD MGI:2682307
Canis familiaris RIC8B VGNC VGNC:45573
Rattus norvegicus RIC8B RGD RGD:631419
Bos taurus RIC8B VGNC VGNC:33962
Felis catus RIC8B VGNC VGNC:64625
Macaca mulatta RIC8B VGNC VGNC:76822
Others RIC8B NCBI