FGGY - FGGY carbohydrate kinase domain containing Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55277

About FGGY

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,296,378-59,762,730 (from NCBI)

This gene has 25 transcripts (splice variants), 204 orthologues and 6 paralogues. Ubiquitous expression in liver (RPKM 2.1), kidney (RPKM 1.3) and 25 other tissues.

Summary

This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of Other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

FGGY Products (14)

mRNA Protein Name
NM_001113411.2 NP_001106882.1 FGGY carbohydrate kinase domain-containing protein isoform a
NM_001244714.2 NP_001231643.1 FGGY carbohydrate kinase domain-containing protein isoform c
NM_001278224.2 NP_001265153.1 FGGY carbohydrate kinase domain-containing protein isoform d
NM_001350790.2 NP_001337719.1 FGGY carbohydrate kinase domain-containing protein isoform a
NM_001350791.2 NP_001337720.1 FGGY carbohydrate kinase domain-containing protein isoform b
NM_001350792.2 NP_001337721.1 FGGY carbohydrate kinase domain-containing protein isoform e
NM_001350793.2 NP_001337722.1 FGGY carbohydrate kinase domain-containing protein isoform e
NM_001350794.2 NP_001337723.1 FGGY carbohydrate kinase domain-containing protein isoform f
NM_001350795.2 NP_001337724.1 FGGY carbohydrate kinase domain-containing protein isoform g
NM_001350796.2 NP_001337725.1 FGGY carbohydrate kinase domain-containing protein isoform h
NM_001350797.2 NP_001337726.1 FGGY carbohydrate kinase domain-containing protein isoform i
NM_001350798.2 NP_001337727.1 FGGY carbohydrate kinase domain-containing protein isoform j
NM_001350799.2 NP_001337728.1 FGGY carbohydrate kinase domain-containing protein isoform k
NM_018291.5 NP_060761.3 FGGY carbohydrate kinase domain-containing protein isoform b

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in carbohydrate phosphorylation IDA
IDA: Inferred from direct assay
27909055 GOA
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
17671248 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGGY Protein Structure

FGGY_N

FGGY_N: FGGY family of carbohydrate kinases, N-terminal domain (11 - 267)

FGGY_C

FGGY_C: FGGY family of carbohydrate kinases, C-terminal domain (290 - 496)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 551 a.a.
Protein Preferred Names Protein Names

FGGY carbohydrate kinase domain-containing protein

  • D-ribulokinase

Related Diseases

Diseases Alias
Lateral Sclerosis

  • Primary Lateral Sclerosis

  • Adult-Onset Primary Lateral Sclerosis

  • Adult-Onset Pls

  • Motor Neuron Disease

  • Pls

  • Pls - [Primary Lateral Sclerosis]

  • Lateral Spinal Sclerosis

  • Lateral Complete Paralysis

  • Lateral Incomplete Paralysis

  • Lateral Paralysis
Spastic Paraplegia 7, Autosomal Recessive

  • SPG7

  • Hereditary Spastic Paraplegia 7

  • Spastic Paraplegia Type 7

  • Spastic Paraplegia 7

  • Hereditary Spastic Paraplegia, Paraplegin Type

  • Autosomal Recessive Spastic Paraplegia 7

  • Hereditary Spastic Paraplegia Paraplegin Type

  • Spastic Paraplegia-7

  • Paraplegia, Spastic, Autosomal Recessive, Type 7

  • Spastic Paraplegia, Hereditary

  • Autosomal Recessive Hereditary Spastic Paraplegia
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Glycerol Kinase Deficiency

  • Hyperglycerolemia

  • GKD

  • Gk Deficiency

  • Gk1 Deficiency

  • Deficiency Of Glycerol Kinase

  • Isolated Glycerol Kinase Deficiency

  • Glycerol Kinase Deficiency, Adult Form

  • Glycerol Kinase Deficiency, Juvenile Form

  • Deficiency, Glycerol Kinase
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

  • FTDALS1

  • Frontotemporal Dementia And/Or Motor Neuron Disease

  • Ftdmnd

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

  • Alsftd

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

  • Frontotemporal Dementia With Motor Neuron Disease

  • Ftdals

  • Ftd-Als

  • Ftd-Mnd

  • Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

  • Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

  • Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

  • Frontotemporal Lobar Degeneration

  • Grn-Related Frontotemporal Dementia
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04926 FGGY Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FGGY VGNC VGNC:28991
Macaca mulatta FGGY VGNC VGNC:72576
Rattus norvegicus FGGY RGD RGD:1359429
Canis familiaris FGGY VGNC VGNC:40863
Mus musculus FGGY MGD MGI:1922828
Others FGGY NCBI