CHDH - choline dehydrogenase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55349

About CHDH

This gene has 3 transcripts (splice variants) and 197 orthologues. Broad expression in kidney (RPKM 17.5), liver (RPKM 4.8) and 14 other tissues.

Summary

The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. [provided by RefSeq, Dec 2010]

CHDH Products (1)

mRNA Protein Name
NM_018397.5 NP_060867.2 choline dehydrogenase, mitochondrial

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHDH Protein Structure

GMC_oxred_N

GMC_oxred_N: GMC oxidoreductase (41 - 338)

GMC_oxred_C

GMC_oxred_C: GMC oxidoreductase (430 - 567)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

choline dehydrogenase, mitochondrial

  • CDH

CHDH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHDH Q8NE62 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra
CHDH Q8NE62 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra
CHDH Q8NE62 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra
CHDH Q8NE62 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Choline Deficiency Disease

  • Choline Deficiency
Froelich Syndrome

  • Froehlich'S Syndrome

  • Froelich'S Syndrome

  • Adiposogenital Syndrome

  • Babinski-Froelich Syndrome

  • Froehlich Syndrome
Trimethylaminuria

  • TMAU

  • Fish-Odor Syndrome

  • Fish Malodor Syndrome

  • Fish Odor Syndrome

  • Stale Fish Syndrome

  • Tmauria

  • Severe Primary Trimethylaminuria

  • Mesh

  • D008661

  • Fish Odour Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70406 Cholesterol Dehydrogenase, Nocardia sp. / Unkown
HY-RS02615 CHDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22116 Chdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28638 Chdh Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CHDH VGNC VGNC:60850
Mus musculus CHDH MGD MGI:1860776
Rattus norvegicus CHDH RGD RGD:735166
Bos taurus CHDH VGNC VGNC:27285
Canis familiaris CHDH VGNC VGNC:39208
Macaca mulatta CHDH VGNC VGNC:71086
Others CHDH NCBI