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DEPDC1 - DEP domain containing 1 Gene

Also Known as DEP.8; SDP35; DEPDC1A; DEPDC1-V2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55635

About DEPDC1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,474,152-68,497,082 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 3 paralogues. Biased expression in testis (RPKM 5.4), lymph node (RPKM 3.0) and 13 other tissues.

Summary

Predicted to enable GTPase activator activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

DEPDC1 Products (2)

mRNA	Protein	Name
NM_001114120.3	NP_001107592.1	DEP domain-containing protein 1A isoform a
NM_017779.6	NP_060249.2	DEP domain-containing protein 1A isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20587513	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20587513	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20587513	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	20587513	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEPDC1 Protein Structure

DEP

0
200
400
600
811 a.a.

Protein Preferred Names	Protein Names
DEP domain-containing protein 1A	cell cycle control protein SDP35

DEPDC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810296	DEPDC1 Antibody	WB	Human, Mouse

Related Diseases

Diseases	Alias
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03693	DEPDC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03694	DEPDC1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27053	Depdc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DEPDC1	VGNC	VGNC:39896
Rattus norvegicus	DEPDC1	RGD	RGD:1306987
Bos taurus	DEPDC1	VGNC	VGNC:55165
Mus musculus	DEPDC1	MGD	MGI:1923381
Macaca mulatta	DEPDC1	VGNC	VGNC:99886
Felis catus	DEPDC1	VGNC	VGNC:61443