CSGALNACT1 - chondroitin sulfate N-acetylgalactosaminyltransferase 1 Gene

Also Known as ChGn; ChGn-1; SDJLABA; CSGalNAcT-1; beta4GalNAcT

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 55790

Summary

This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]

CSGALNACT1 Products (1)

mRNA Protein Name
NM_001354476.2 NP_001341405.1 chondroitin sulfate N-acetylgalactosaminyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
11514575 GOA
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
12163485 GOA
enables glucuronosyltransferase activity IDA
IDA: Inferred from direct assay
11514575 GOA
enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
12163485 GOA
enables peptidoglycan glycosyltransferase activity IDA
IDA: Inferred from direct assay
11514575 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in UDP-N-acetylgalactosamine metabolic process IDA
IDA: Inferred from direct assay
11514575 GOA
involved in UDP-glucuronate metabolic process IDA
IDA: Inferred from direct assay
11514575 GOA
involved in chondroitin sulfate biosynthetic process IDA
IDA: Inferred from direct assay
11514575 GOA
involved in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
IDA: Inferred from direct assay
12163485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chondroitin sulfate N-acetylgalactosaminyltransferase 1

  • beta4GalNAcT-1

  • chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1

  • chondroitin beta1,4 N-acetylgalactosaminyltransferase

  • glucuronylgalactosylproteoglycan 4-beta-N- acetylgalactosaminyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5045 Fmoc-Thr(GalNAc(Ac)3-β-D)-OH / Unkown
HY-RS16407 CSGALNACT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21280 Csgalnact1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27799 Csgalnact1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown