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ARHGAP15 - Rho GTPase activating protein 15 Gene

Also Known as BM046

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55843

About ARHGAP15

Cytogenetic location: 2q22.2-q22.3 Genomic coordinates (GRCh38): 2:143,129,419-143,768,352 (from NCBI)

This gene has 13 transcripts (splice variants), 201 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 10.3), bone marrow (RPKM 9.8) and 18 other tissues.

Summary

RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

ARHGAP15 Products (1)

mRNA	Protein	Name
NM_018460.4	NP_060930.3	rho GTPase-activating protein 15

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	12650940	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within regulation of cell shape	IDA IDA: Inferred from direct assay	12650940	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP15 Protein Structure

RhoGAP

0
100
200
300
400
475 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 15	rho-type GTPase-activating protein 15

ARHGAP15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARHGAP15	Q53QZ3	DHPS	Homo sapiens	P49366	Anti Tag CoIP	33961781
Intra	ARHGAP15	Q53QZ3	DHPS	Homo sapiens	P49366	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diverticulitis
Mowat-Wilson Syndrome	MOWS Microcephaly, Mental Retardation, And Distinct Facial Features, With Or Without Hirschsprung Disease Hirschsprung Disease-Mental Retardation Syndrome Mowat-Wilson Syndrome Due To Monosomy 2q22 Hirschsprung Disease Mental Retardation Syndrome Microcephaly, Mental Retardation, And Distinct Facial Featrues, With Or Without Hirschprung Disease Hirschsprung Disease - Intellectual Disability Syndrome Hirschsprung Disease Intellectual Disability Syndrome Intellectual Disability, Microcephaly, And Distinct Facial Features With Or Without Hirschsprung Disease Mws Hirschsprung Disease-Intellectual Disability Syndrome Hirschsprung Disease And Intellectual Disability Due To 2q22 Microdeletion Hirschsprung Disease And Intellectual Disability Due To Del(2)(Q22) Hirschsprung Disease And Intellectual Disability Due To Monosomy 2q22 Mowat-Wilson Syndrome Due To 2q22 Microdeletion Mowat-Wilson Syndrome Due To Del(2)Q(22) Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation Hirschsprung Disease And Intellectual Disability Due To A Zeb2 Point Mutation
Meier-Gorlin Syndrome 2	MGORS2 Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9	Epilepsy, Idiopathic Generalized, Susceptibility To, 9 EIG9 Epilepsy, Juvenile Myoclonic 6 Idiopathic Generalized Epilepsy 9 Epilepsy, Juvenile Myoclonic, Susceptibility To, 6 Susceptibility To Idiopathic Generalized Epilepsy 9 Juvenile Myoclonic Epilepsy 6 EJM6 Susceptibility To Juvenile Myoclonic Epilepsy 6 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9
Diverticulitis Of Colon	Colonic Diverticular Disease Diverticulitis, Colonic Diverticular Disease Of Colon
Bladder Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Bladder Epidermoid Carcinoma Of The Urinary Bladder Carcinoma Squamous Cell Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00916	ARHGAP15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARHGAP15	MGD	MGI:1923367
Felis catus	ARHGAP15	VGNC	VGNC:59876
Bos taurus	ARHGAP15	VGNC	VGNC:26076
Rattus norvegicus	ARHGAP15	RGD	RGD:1359304
Canis familiaris	ARHGAP15	VGNC	VGNC:38047
Macaca mulatta	ARHGAP15	VGNC	VGNC:69874
Others	ARHGAP15	NCBI